Tissue factor storage, synthesis and function in normal and activated human platelets
Tissue factor storage, synthesis and function in normal and activated human platelets
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DOI：
10.1016/s0049-3848(08)70016-1
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发表时间：
2008-01-01
影响因子：
7.5
通讯作者：
Panes, Olga
中科院分区：
文献类型：
--
作者：
Mezzano, Diego;Matus, Valeria;Panes, Olga
血源性组织因子(Tf)的来源和意义一直存在争议。Tf在血小板中的存在最初归因于蛋白质从其他细胞(如单核细胞)和/或携带Tf的微粒的转移。近年来，在人类血小板中发现了TF-mRNA、蛋白的新合成和依赖于TF的促凝剂活性(PCA)。“加密的”、潜在的活性转铁蛋白在循环的、非刺激的血小板中的存储仍然存在争议。一份报告有力地表明，血小板PCA的启动依赖于由血小板激活诱导的新的TF合成，而另一些报告则提供了令人信服的证据，表明血小板与预先形成的TF一起循环，容易在需要时发挥功能。这些发现可能会对我们目前关于生理性止血和血栓形成的想法产生影响。事实上，血小板不仅会导致原发血栓的形成，而且在这个微环境中，它们还会触发凝血酶的生成、纤维蛋白沉积、凝块固结和最初的纤溶保护作用。需要大量研究来验证这种基于血小板的止血模型。(C)2008爱思唯尔有限公司。保留所有权利。
The source and significance of blood-borne tissue factor (TF) are controversial. The presence of TF in platelets was initially attributed to transfer of the protein from other cells (e.g., monocytes) and/or TF-bearing microparticles. Recently, TF-mRNA, neo-synthesis of the protein and TF-dependent procoagulant activity (PCA) have been reported in human platelets. The storage of "encrypted", potentially active TF in circulating, non-stimulated platelets remains debatable. One report strongly suggests that the starting of platelet PCA depends on de.novo, TF synthesis induced by platelet activation, whereas others provide persuasive evidence that platelets circulate with preformed TF, readily functional upon demand. These findings may have an impact on our current ideas of physiological hemostasis and thrombus formation. In fact, platelets would lead not only the formation of the primary plug, but in this microenvironment they would also contribute to the triggering of thrombin generation, fibrin deposition, clot consolidation and initial protection from fibrinolysis. Much research is needed to validate this platelet-based hemostasis model. (c) 2008 Elsevier Ltd. All rights reserved.