Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.
Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.
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v-fgr onc 的基因产物：含有肌动蛋白一部分和酪氨酸特异性蛋白激酶的杂合蛋白。
作者：
G. Naharro;K. Robbins;E. Reddy
加德纳-拉希德猫肉瘤病毒 (GR-FeSV) 编码其初级翻译产物 p70gag-fgr 的区域的核苷酸序列已确定。从核苷酸序列推导出该转化蛋白的氨基酸序列。计算机分析表明，P70gag-fgr 的一部分与肌动蛋白（一种真核细胞骨架蛋白）具有广泛的氨基酸序列同源性。 P70gag-fgr 的第二个区域与酪氨酸特异性激酶基因家族密切相关。因此，v-fgr癌基因似乎是由于涉及两个不同细胞基因的重组事件而产生的，一个编码结构蛋白，另一个编码蛋白激酶。
The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70gag-fgr is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.