Pre-natal irradiation and childhood malignancy: a review of British data from the Oxford Survey.
Pre-natal irradiation and childhood malignancy: a review of British data from the Oxford Survey.
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DOI：
10.1038/bjc.1975.62
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发表时间：
1975-03
影响因子：
8.8
通讯作者：
Stewart, A M
中科院分区：
文献类型：
--
作者：
Bithell, J F;Stewart, A M
本文回顾了牛津儿童癌症调查中与产科放射学有关的数据，即1953年至1967年英国的死亡数据。大约有8513个病例被追踪并用于分析，还有相同数量的匹配对照组。不同肿瘤组、不同死亡年龄、不同性别之间的相对风险估计值(总体为1-47)没有显著差异。对其他流行病学因素--兄弟姐妹地位、产妇年龄、社会阶层、居住地和产妇发病率--进行了分析，并显示出不同程度的关联，但不足以从选择效应的角度“解释”观察到的风险。风险与曝光胶片数量的相关性是非常显著的，并且可以用线性关系来充分描述。对暴露的时机和原因也进行了研究。对出生年份的风险分析显示，实体和造血肿瘤的风险稳步下降；这可能部分归因于每张曝光的胶片的辐射剂量较低，但也是因为使用的胶片数量较少。结果很可能是，在未来的研究中，这种风险--总是具有很小的临床意义--将变得几乎无法检测到。
This paper reviews data relating to obstetric radiography from the Oxford Survey of Childhood Cancers, i.e. for deaths in Britain from 1953 to 1967. Some 8513 cases were traced and used in the analyses, together with an equal number of matched controls. The relative risk estimate (1-47 overall) does not vary significantly between different tumour groups, for different ages at death, nor between sexes. Other epidemiological factors-sibship position, maternal age, social class, region of residence and maternal morbidity-are analysed and show varying degrees of association, but not sufficient to "explain" the observed risk in terms of a selection effect. The dependence of the risk on the number of films exposed is highly significant and adequately described by a linear relationship. The timing of and reason for the exposure are also examined. Analysis of the risk by year of birth shows a pattern of steadily declining risk for both solid and haematopoietic tumours; this may be partly attributable to lower radiation doses per film exposed but is also due to the smaller numbers of films used. A consequence may well be that the risk-always of small clinical significance-would become virtually undetectable in future investigations.