A direct projection from superior colliculus to substantia nigra for detecting salient visual events
A direct projection from superior colliculus to substantia nigra for detecting salient visual events
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DOI：
10.1038/nn1113
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发表时间：
2003-09-01
影响因子：
25
通讯作者：
Redgrave, P
中科院分区：
文献类型：
--
作者：
Comoli, E;Coizet, V;Redgrave, P
中脑多巴胺能神经元对意外的和生物学上显著的事件作出反应，但对这种反应背后的感觉系统知之甚少。在这里，我们描述了，在大鼠中，从一个主要的视觉结构，中脑上级丘（SC），黑质pars延髓（SNc）的直接投射，直接突触接触与多巴胺能和非多巴胺能神经元。补充的电生理数据显示，短潜伏期的视觉反应在SNC被取消同侧病变的SC和增加局部刺激丘。这些结果表明，tectonigral投影是理想的位置，以中继短潜伏期的视觉信息，多巴胺的腹侧中脑的区域。我们的结论是，它是在这个传入的感觉回路，关键的感知歧视，识别刺激作为不可预测的和生物学显着的。
Midbrain dopaminergic neurons respond to unexpected and biologically salient events, but little is known about the sensory systems underlying this response. Here we describe, in the rat, a direct projection from a primary visual structure, the midbrain superior colliculus (SC), to the substantia nigra pars compacta (SNc) where direct synaptic contacts are made with both dopaminergic and non-dopaminergic neurons. Complementary electrophysiological data reveal that short-latency visual responses in the SNc are abolished by ipsilateral lesions of the SC and increased by local collicular stimulation. These results show that the tectonigral projection is ideally located to relay short-latency visual information to dopamine-containing regions of the ventral midbrain. We conclude that it is within this afferent sensory circuitry that the critical perceptual discriminations that identify stimuli as both unpredicted and biologically salient are made.