Human motor associative plasticity induced by paired bihemispheric stimulation
Human motor associative plasticity induced by paired bihemispheric stimulation
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DOI：
10.1113/jphysiol.2009.174342
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发表时间：
2009-10-01
影响因子：
5.5
通讯作者：
Domen, Kazuhisa
中科院分区：
文献类型：
--
作者：
Koganemaru, Satoko;Mima, Tatsuya;Domen, Kazuhisa
配对联合刺激（Paired associative stimulation，PAS）是一种有效的非侵入性方法，通过在初级运动皮层（M1）以特定的时间间隔重复配对外周神经刺激和经颅磁刺激（transcranial magnetic stimulation，TMS）来诱导人体运动可塑性。虽然两种类型的传入刺激的重复配对可能是神经可塑性和记忆的生物学基础，但人类大脑的其他类型的配对刺激很少被研究。我们假设，TMS和半球间皮质-皮质投射或配对双半球刺激（PBS），其中右侧和左侧M1连续刺激的时间间隔为15 ms的重复配对，将产生联想长时程增强（LTP）样效应。在这项研究中，23名右利手的健康志愿者进行了0.1 Hz重复的180对双半球TMS，运动系统的生理和行为的措施进行了比较之前，之后立即，20分钟后和40分钟后PBS干预。左侧M1刺激诱导的运动诱发电位（MEP）的幅度及其输入-输出功能增加，持续时间与PBS后20 min相似。PBS也促进了精细的手指运动。脊髓兴奋性测量的H-反射是不敏感的PBS，这表明皮质机制。PBS诱导的相关LTP样效应具有时间依赖性，仅在刺激间隔为5-25 ms时发生。这些结果表明，在PAS中使用PBS可以诱导运动皮层可塑性，这种方法可能适用于运动障碍患者的康复。
Paired associative stimulation (PAS) is an effective non-invasive method to induce human motor plasticity by the repetitive pairing of peripheral nerve stimulation and transcranial magnetic stimulation (TMS) at the primary motor cortex (M1) with a specific time interval. Although the repetitive pairing of two types of afferent stimulation might be a biological basis of neural plasticity and memory, other types of paired stimulation of the human brain have rarely been studied. We hypothesized that the repetitive pairing of TMS and interhemispheric cortico-cortical projection or paired bihemispheric stimulation (PBS), in which the right and left M1 were serially stimulated with a time interval of 15 ms, would produce an associative long-term potentiation (LTP)-like effect. In this study, 23 right-handed healthy volunteers were subjected to a 0.1 Hz repetition of 180 pairings of bihemispheric TMS, and physiological and behavioural measures of the motor system were compared before, immediately after, 20 min after and 40 min after PBS intervention. The amplitude of the motor evoked potential (MEP) induced by the left M1 stimulation and its input-output function increased for up to similar to 20 min post-PBS. Fine finger movements were also facilitated by PBS. Spinal excitability measured by the H-reflex was insensitive to PBS, suggesting a cortical mechanism. The associative LTP-like effect induced by PBS was timing dependent, occurring only when the interstimulus interval was 5-25 ms. These findings demonstrate that using PBS in PAS can induce motor cortical plasticity, and this approach might be applicable to the rehabilitation of patients with motor disorders.