AC-BioSD : A biomolecular signal differentiator module with enhanced performance
AC-BioSD : A biomolecular signal differentiator module with enhanced performance
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AC-BioSD：具有增强性能的生物分子信号微分器模块
DOI：
10.1101/2024.01.29.577841
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Alexis E
中科院分区：
文献类型：
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作者：
Alexis E
时间梯度估计是自然生物系统中普遍存在的现象，对于具有广泛应用的合成对应物具有广阔的前景。在这里，我们通过引入一种新颖的生物分子拓扑（称为自催化-BioSD 或 AC-BioSD）来推进 BioSD（生物分子信号微分器）的概念。即使在远离标称条件的情况下，其结构也能对输入信号变化不敏感，并且在信号区分方面具有高精度。同时，破坏性的高频信号分量被有效衰减。此外，通过 PID（比例积分微分）生物控制方案，在确定性和随机域中具有设定点加权和过滤微分作用，突出了我们的拓扑在生物调节中的有用性。
Temporal gradient estimation is a pervasive phenomenon in natural biological systems and holds great promise for synthetic counterparts with broad-reaching applications. Here, we advance the concept ofBioSD(Biomolecular Signal Differentiators) by introducing a novel biomolecular topology, termedAutocatalytic-BioSDorAC-BioSD. Its structure allows for insensitivity to input signal changes and high precision in terms of signal differentiation, even when operating far from nominal conditions. Concurrently, disruptive high-frequency signal components are effectively attenuated. In addition, the usefulness of our topology in biological regulation is highlighted via a PID (Proportional-Integral-Derivative) bio-control scheme withset point weightingand filtered derivative action in both the deterministic and stochastic domains.