SPINAL ELECTROGRAM OF FREELY MOVING CAT - SUPRASPINAL AND SEGMENTAL INFLUENCES
SPINAL ELECTROGRAM OF FREELY MOVING CAT - SUPRASPINAL AND SEGMENTAL INFLUENCES
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DOI：
10.1016/0006-8993(70)90005-3
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发表时间：
1970-01-01
期刊：
影响因子：
2.9
通讯作者：
GASTEIGER, EL
中科院分区：
文献类型：
--
作者：
KASPRZAK, H;GASTEIGER, EL
与脑机制相反，脊髓水平的机制已被研究，麻醉或横断的中枢神经系统（CNS）除外。在这些条件下，脊髓电图（SEG）先前已在青蛙和几种哺乳动物中进行了研究，结果相当有限，而且往往相互矛盾。最近，Brust-Carmona等人5和Levitan等人~ 2重新检查了猫的SEG，并将其分解为两个分量：负尖波（NSW）和背景活动（BA）。然而，他们未能揭示这种现象的结构起源或生理意义。SEG与功能的联系一再失败，使得有必要确定在正常行为条件下它是否确实存在于完整的神经系统中，几个观察结果表明SEG的存在取决于CNS的修饰。NSW是脊髓和去大脑准备中SEG的一个突出特征，使脊髓活动不像正常EEG，但更像癫痫脑电波的尖峰成分。新南威尔士州，因为其更大的幅度时，与BA相比，可能会被认为是一个“爆炸性”的事件不发生在生理条件下。其在分离的无麻醉剂脊髓中的波形显示出与大脑皮层中的戊巴比妥尖峰相似12。在急性条件下持续数小时的NSW及其在慢性隔离脊髓中的存在将其与损伤电位区分开来，但并不能将其确定为正常现象。反对在完整动物中存在SEG与NSW的最有力证据来自缺血实验5。脊髓缺血产生的降主动脉闭塞30分钟并没有改变一般的行为能力的动物在3-10天的缺血后时期。然而，随后记录的SEG在去大脑和脊髓条件下的NSW的情况下，尽管存在反射活动的标记。在本研究中，SEG的结构起源和生理意义的问题进行了研究的活动在完整的中枢神经系统的猫与电极长期植入脊髓。已发表的研究
In contrast to cerebral mechanisms, those at spinal level have been investigated with few exceptions in anesthetized or transected central nervous systems (CNS). Under these conditions the spinal electrogram (SEG) has been previously studied in the frog and several mammals with rather limited and often conflicting results la. Recently Brust-Carmona et al. 5 and Levitan et al.~ 2 re-examined the SEG in the cat and resolved it into two components: negative sharp waves (NSWs) and background activity (BA). However, they failed to uncover the structural origin or physiological significance of the phenomenon. Repeated failure to relate the SEG to function makes it necessary to determine if it actually exists in the intact nervous system under normal behavioral conditions.Several observations would indicate that the presence of the SEG depends upon modification of the CNS. The NSWs, being an outstanding feature of the SEG in spinal and decerebrate preparations, render the cord activity less like the normal EEG but more reminiscent of the spike component of epileptic brain waves. The NSW, because of its greater amplitude when compared with BA, might be considered an'explosive'event not occurring under physiological conditions. Its waveform in isolated anesthetic-free cord has shown resemblance to Nembutal spikes in the cerebral cortex 12. Persistance of NSWs for hours under acute conditions and their existence in chronically isolated cord set them apart from injury potentials 25 but do not establish them as a normal phenomenon. The strongest evidence against the existence of SEG with NSWs in intact animals comes from ischemia experiments 5. Spinal cord ischemia produced by a 30 min occlusion of the descending aorta did not alter the general behavioral capabilities of animals during a 3-10-day post-ischemic period. However, subsequent recordings of the SEG in decerebrate and spinal conditions were marked by the absence of the NSWs despite the presence of reflex activity. In the present study, the questions of structural origin and physiological significance of the SEG were pursued by examination of the activity in intact CNS of cats with electrodes chronically implanted in the spinal cord. Published studies of