Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands
Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands
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对映体纯螺联苯恶西林二醇及其相关手性配体的简明合成及应用
DOI：
10.1039/d1cc05576c
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wang Peng
中科院分区：
文献类型：
--
作者：
Yang Lei;Xu Wen-Qiang;Liu Tao;Wu Yichen;Wang Biqin;Wang Peng
手性配体和催化剂发现的手性结构的发展对于不对称催化至关重要。在此，我们报告了以硅为中心的螺环骨架、螺联苯恶硅二醇（SPOSiOL）及其衍生的手性配体的简明合成。使用化学拆分方法，可以高产率获得克级的光学SPOSiOL。初步研究表明该配体支架在过渡金属催化的不对称反应中具有巨大的潜力。这一发现进一步强调了以硅为中心的螺环支架在不对称催化中具有重要价值。
The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis.