Cerebellar injury in the extremely premature infant: Newly recognized but relatively common outcome
Cerebellar injury in the extremely premature infant: Newly recognized but relatively common outcome
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DOI：
10.1177/08830738050200021101
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发表时间：
2005-02-01
影响因子：
1.9
通讯作者：
Johnsen, SD
中科院分区：
文献类型：
--
作者：
Bodensteiner, JB;Johnsen, SD
最近报道了13例临床诊断为脑性瘫痪的儿童，小脑严重损伤是极早产儿和极低出生体重的并发症。我们报告了另外10例这种综合征。临床特征包括显著的运动障碍和不同程度的共济失调和手足徐动症或肌张力障碍，代表了脑性瘫痪的一种独特的临床类型。大多数都严重受损，有认知、语言和运动障碍。除1例有脑积水外，其余均为小头畸形。神经影像检查显示，小脑的大部分没有累及下蠕虫和大脑半球。大多数人的大脑也有不太严重的损伤。这份报告表明，这在极低出生体重儿中并不少见，我们希望鼓励进一步研究这种情况的相对频率和可能的病因。
Severe injury to the cerebellum as a complication of extreme prematurity with extremely low birthweight was recently described in 13 children with the clinical diagnosis of cerebral palsy. We report another 10 cases of this syndrome. The clinical features include striking motor impairment and variable degrees of ataxia and athetosis or dystonia, which represent a distinct clinical type of cerebral palsy. Most are severely damaged, with cognitive, language, and motor delays. All are microcephalic, except one with hydrocephalus. Neuroimaging studies demonstrate the absence of major portions of the cerebellum involving both the inferior vermis and hemispheres. Most also have injury of a less severe nature in the cerebrum. This report indicates that this is not an uncommon outcome of extremely low birthweight infants, and we hope to encourage further investigations into the relative frequency and likely etiologies of the condition.