The relative toxicity of nonsteroidal antiinflammatory drugs.
The relative toxicity of nonsteroidal antiinflammatory drugs.
复制标题
非甾体抗炎药的相对毒性。
DOI：
10.1002/art.1780341103
复制
发表时间：
1991
影响因子：
--
通讯作者：
Bloch,DA
中科院分区：
文献类型：
--
作者：
Fries,JF;Williams,CA;Bloch,DA
根据症状、实验室异常和归因于非甾体类抗炎药（NSAID）治疗的住院情况计算毒性指数评分，2，747例类风湿性关节炎患者在8，481患者年内接受了5，642个疗程的11种NSAID。发现总体毒性存在显著差异，药物之间的差异通常具有临床意义（毒性的2 - 3倍）和高度统计学意义。在针对不同患者特征进行调整后，结果得到了加强，通常在多个ARAMIS（关节炎，风湿病和衰老医学信息系统）数据库中心中保持，并在使用不同技术对副作用进行加权后持续存在。不良反应以消炎痛（平均值± SEM评分3.99 ± 0.58）、托美汀钠（3.96 ± 0.74）和甲氨酰钠（3.86 ± 0.66）最多。毒性最小的是包衣或缓冲阿司匹林（1.19 ± 0.10）、双水杨酯（1.28 ± 0.34）和布洛芬（1.94 ± 0.43）。毒性最大的药物通常以最低的相对剂量服用。类风湿性关节炎中使用的不同NSAID之间的总体毒性存在统计学差异，这些差异具有临床和统计学意义。
Toxicity Index scores were computed from symptoms, laboratory abnormalities, and hospitalizations attributed to nonsteroidal antiinflammatory drug (NSAID) therapy in 2,747 patients with rheumatoid arthritis receiving 5,642 courses of 11 NSAIDs over 8,481 patient‐years. Substantial differences in overall toxicity were found, the differences between drugs often being clinically significant (2‐3 times as toxic) and highly statistically significant. The results strengthened after adjustment for differing patient characteristics, held generally across multiple ARAMIS (Arthritis, Rheumatism, and Aging Medical Information System) data bank centers, and persisted after use of different techniques for the weighting of side effects. The most toxic side effects were experienced by patients taking indomethacin (mean ± SEM score 3.99 ± 0.58), tolmetin sodium (3.96 ± 0.74), and meclofenamate sodium (3.86 ± 0.66). Least toxic were coated or buffered aspirin (1.19 ± 0.10), salsalate (1.28 ± 0.34), and ibuprofen (1.94 ± 0.43). The most toxic drugs were generally taken in the lowest relative doses. There are statistical differences in overall toxicity between different NSAIDs as used in rheumatoid arthritis, and these differences are both clinically and statistically significant.