Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population.
Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population.
复制标题
中国人群中 NF-E2 相关因子 2 基因与氧化应激、抗氧化状态和新诊断 2 型糖尿病的关联
DOI：
10.3390/ijms160716483
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发表时间：
2015-07-20
影响因子：
5.6
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Wang X;Chen H;Liu J;Ouyang Y;Wang D;Bao W;Liu L
氧化应激是2型糖尿病（T2 DM）发病和进展的主要危险因素。NF-E2相关因子2（NRF 2）是氧化应激相关疾病中的关键转录因子。该研究包括2174例受试者，其中879例新诊断的T2 DM患者和1295例健康对照。与CC基因型个体相比，AA基因型个体的总抗氧化能力、超氧化物歧化酶、过氧化氢酶、谷胱甘肽、谷胱甘肽过氧化物酶活性较低，β细胞功能指数稳态模型评估值较低。AA基因型的人也有较高的丙二醛浓度和稳态模型评估的胰岛素抵抗指数值。T2 DM受试者（29.4%）中等位基因A的频率显著高于对照受试者（26.1%; p = 0.019）。与CC基因型个体相比，AA基因型个体发生T2 DM的风险显著更高（OR 1.56; 95% CI 1.11，2.20; p = 0.011），即使在调整已知的T2 DM风险因素后。我们的研究结果表明，NRF 2 rs6721961多态性与氧化应激，抗氧化状态和新诊断的T2 DM的风险显着相关。该多态性也可能导致中国人群胰岛素分泌能力受损和胰岛素抵抗增加。
Oxidative stress is a major risk factor in the onset and progression of type 2 diabetes mellitus (T2DM). NF-E2 related factor 2 (NRF2) is a pivotal transcription factor in oxidative stress related illnesses. This study included 2174 subjects with 879 cases of newly-diagnosed T2DM and 1295 healthy controls. Compared to individuals with the CC genotype, those with the AA genotype had lower total anti-oxidative capacity, superoxide dismutase, catalase, glutathione, glutathione peroxidase activity; and lower homeostasis model assessment of β-cell function index. Those with the AA genotype also had a higher malondialdehyde concentration and homeostasis model assessment of insulin resistance index values. The frequency of allele A was significantly higher in T2DM subjects (29.4%), compared to control subjects (26.1%; p = 0.019). Individuals with the AA genotype had a significantly higher risk of developing T2DM (OR 1.56; 95% CI 1.11, 2.20; p = 0.011), relative to those with the CC genotype, even after adjusting for known T2DM risk factors. Our results suggest that the NRF2 rs6721961 polymorphism was significantly associated with oxidative stress, anti-oxidative status, and risk of newly-diagnosed T2DM. This polymorphism may also contribute to impaired insulin secretory capacity and increased insulin resistance in a Chinese population.