Robustness in regulatory networks:: A multi-disciplinary approach
Robustness in regulatory networks:: A multi-disciplinary approach
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DOI：
10.1007/s10441-008-9029-x
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发表时间：
2008-06-01
影响因子：
1.3
通讯作者：
Sene, Sylvain
中科院分区：
文献类型：
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作者：
Demongeot, Jacques;Elena, Adrien;Sene, Sylvain
在本文中，我们给出了来自生物调控网络中扰动的主要来源的动态影响（如表型变化）的指示。首先，我们定义了表达网络主要元素（基因、蛋白质、代谢物等）之间的相互作用图的边界。然后，我们搜索边界上状态值的变化会导致系统核心状态的变化（对边界条件的鲁棒性）。之后，我们分析了更新模式（顺序，块顺序或并行）对网络渐近性的作用，本质上是对极限环的发生（对更新方法的鲁棒性）。最后，我们展示了一些拓扑变化（例如抑制或增加相互作用）对系统动态行为的影响（对拓扑扰动的鲁棒性）。
We give in this paper indications about the dynamical impact (as phenotypic changes) coming from the main sources of perturbation in biological regulatory networks. First, we define the boundary of the interaction graph expressing the regulations between the main elements of the network (genes, proteins, metabolites, ...). Then, we search what changes in the state values on the boundary could cause some changes of states in the core of the system (robustness to boundary conditions). After, we analyse the role of the mode of updating (sequential, block sequential or parallel) on the asymptotics of the network, essentially on the occurrence of limit cycles (robustness to updating methods). Finally, we show the influence of some topological changes (e.g. suppression or addition of interactions) on the dynamical behaviour of the system (robustness to topology perturbations).