Cataract Induction in Mice Exposed to Near UV Light
Cataract Induction in Mice Exposed to Near UV Light
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暴露于近紫外光的小鼠白内障诱导
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
J. Schultz
中科院分区：
文献类型：
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作者：
S. Zigman;T. Yulo;J. Schultz
当年轻小鼠每天暴露在 40 瓦黑光灯下 12 小时时，35 周后观察到它们晶状体的微观解剖和生化变化。从此时起，在晶状体皮层中发现了许多具有固缩核的未分化小鼠ed细胞。可溶性结晶的积累受到抑制，尤其是γ-晶状体蛋白。在受紫外线照射的小鼠晶状体中发现了高水平的不溶性蛋白质。高分子量聚集体在该不溶相中增加。从 60 周起，出现皮质混浊。因此，现在已证明白内障是由长期暴露于低水平近紫外光的小鼠晶状体的生化和解剖学变化引起的。
When young mice were exposed to 40-watt black light lamps for 12 h a day, microanatomical and biochemical changes were observed in their lenses after 35 weeks. From this time on, many undifferentiat-Mice ed cells with pyknotic nuclei were found in the lens cortex. Accumulation of soluble crystalline was depressed, especially γ-crystallin. High levels of insoluble protein were found in lenses of UV-irradiated mice. High molecular weight aggregates increased in this insoluble phase. From 60 weeks on, cortical opacities were seen. Thus, cataracts have now been shown to result from biochemical and anatomical changes in lenses of mice exposed to low levels of near UV light for extended time periods.