Uptake and Kinetics of Tc-99m Hexakis 2-Methoxy Isobutyl Isonitrile in Benign and Malignant Lesions in the Lungs
Uptake and Kinetics of Tc-99m Hexakis 2-Methoxy Isobutyl Isonitrile in Benign and Malignant Lesions in the Lungs
复制标题
Tc-99m Hexakis 2-甲氧基异丁基异腈在肺部良性和恶性病变中的摄取和动力学
作者：
I. Hassan;A. Sahweil;C. Constantinides;A. Mahmoud;Y. T. Omar;H. Abdel
本文研究了19例肺部病变（6例良性，13例恶性）的~（99）Tc-MIBI摄取动力学。在静脉注射10- 15 mCi（370-550 MBq）后获得两项动态研究;第一项是每秒一次，持续60秒，然后是第二项每分钟一次，持续30分钟。在2小时和3小时获得延迟图像。通过在肺病变（TR）、对侧正常肺（NL）和心脏（Ht）上分配感兴趣区域（ROI），生成时间活动曲线（TAC），并计算达到峰值活动的时间以及TR/NL、Ht/TR和Ht/NL的比率。Ht/NL比也进行了评估，在5名患者提到的诊断缺血性心脏病（IHD）心肌成像。10例未经治疗的肺恶性肿瘤患者的Tc-99 mMIBI摄取局部增加。在1例未经治疗的低分化鳞状细胞癌患者、2例经治疗的肺癌患者和4例肺部非恶性病变患者中未发现局部摄取。2例纤维性肺泡炎患者表现为弥漫性肺摄取增加。在所有阳性研究中，肿瘤在第一分钟内达到峰值。除纤维化肺泡炎患者外，所有组之间的Ht/NL比值均无统计学差异。在5-10分钟和25-30分钟，TR/NL、Ht/R和Ht/NL比值之间无显著差异。25-30分钟TR/NL比值阳性组为1.58 ± 0.36，阴性组为1 ± 0.22。肺良性病变组Ht/TR比值为2.14 ± 0.54，阳性组为1.7 ± 0.45。初步研究表明，恶性肿瘤中的Tc-99 mMIBI摄取在良性和恶性病变之间存在显著差异。很明显，放射治疗抑制这种吸收。
Kinetics of Tc-99m MIBI uptake was studied in 19 patients with lung lesions (6 benign, 13 malignant). Two dynamic studies were acquired after the I.V. injection of 10-15mCi (370-550 MBq); the first was every second for 60 seconds, followed by a second one every minute for 30 minutes. Delayed images were acquired at two and three hours. By assigning regions of interest (ROI) over the lung lesions (TR), contralateral normal lung (NL) and the heart (Ht), time activity curves (TAC) were generated and time to peak activity was calculated as well as the ratios of TR/NL, Ht/TR and Ht/NL. The Ht/NL ratio was also assessed in five patients referred with diagnosis of ischaemic heart disease (IHD) for myocardial imaging. There was a localized increase of Tc-99m MIBI uptake in ten patients with untreated malignant tumours of the lung. No localized uptake was found in one patient with untreated poorly differentiated squamous cell carcinoma, two treated lung cancer and four patients with non-malignant lesions of the lungs. Two patients with fibrosing alveolitis showed diffuse increase lung uptake. In all positive studies peak tumour was reached within the first minute. There was no statistical difference in the ratio of Ht/NL between all groups except in patients with fibrosing alveolitis. There was no significant difference between the ratios TR/NL, Ht/R and Ht/NL at 5-10 minutes and 25-30 minutes. The ratio of TR/NL at 25-30 minutes was 1.58 ± 0.36 in the positive cases versus 1 ± 0.22 in the negative ones. The mean Ht/TR ratio was 1.7 ± 0.45 in the positive ones versus 2.14 ± 0.54 in those with benign lesions of the lungs. This initial study demonstrates the uptake of Tc-99m MIBI in malignant tumours with prominent difference between benign and malignant lesions. It is evident that radiotherapy inhibits this uptake.