Nonsteroidal antiinflammatory drugs are associated with increased aortic stiffness
Nonsteroidal antiinflammatory drugs are associated with increased aortic stiffness
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DOI：
10.2147/vhrm.1.2.149.64082
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发表时间：
2005-07-15
影响因子：
2.9
通讯作者：
Wilmink, Teun
中科院分区：
文献类型：
--
作者：
Claridge, Martin;Hobbs, Simon;Wilmink, Teun
目的：在动物模型中，非类固醇抗炎药(NSAIDs)已被证明可以延缓动脉瘤的生长。体外研究表明，非甾体抗炎药对基质金属蛋白酶-9、白介素1β和白介素6介导的动脉壁弹性溶解有抑制作用。本研究的目的是调查非类固醇抗炎药对动脉僵硬的影响，动脉僵硬是动脉弹性溶解的替代标志物。方法：447名参加社区腹主动脉瘤(AAA)筛查计划的受试者接受了年龄、血压、吸烟状况和吸毒史的评估。用M型超声测量主动脉内径和僵硬度。III型前胶原氨基端前肽浓度作为III型胶原转换率的替代指标。结果：在调整了年龄、主动脉内径、血压和吸烟状况后，非甾体抗炎药摄入量与主动脉壁硬度增加显著相关(p=0.006)。A受体阻滞剂、钙通道拮抗剂、硝酸酯类药物、血管紧张素转换酶抑制剂、利尿剂或抗血小板药物均未见此效应。讨论：这些新数据表明非甾体抗炎药可能通过细胞因子介导的弹性溶解作用与主动脉僵硬有关。这反过来可能会阻止主动脉扩张和AAA的发展。
Objectives: Nonsteroidal antiinflammatory drugs (NSAIDS) have been shown to retard aneurysm growth in animal models. In vitro studies have shown an inhibitory effect of NSAIDS on matrix metalloproteinase-9, interleukin-1 beta, and IL-6 mediated arterial wall elastolysis. The aim of this study was to investigate the effects of NSAIDs on arterial stiffness, a surrogate marker of elastolysis.Methods: 447 subjects enrolled in a community-based abdominal aortic aneurysm ( AAA) screening program were assessed for age, blood pressure, smoking status, and drug history. Aortic diameter and stiffness were measured by M-Mode ultrasound. The concentration of the amino-terminal propeptide of type III procollagen was used as a proxy measurement of type III collagen turnover.Results: NSAID ingestion was significantly (p = 0.006) associated with increased aortic wall stiffness after adjusting for age, aortic diameter, blood pressure, and smoking status. No such effect was seen for a-blockers, calcium channel antagonists, nitrates, angiotensin-converting enzyme inhibitors, diuretics, or antiplatelet agents.Discussion: These novel data show that NSAIDS are associated with increased aortic stiffness, possibly through the effects of cytokine mediated elastolysis. This in turn may prevent aortic expansion and the development of AAA.