EFFECTS OF DOPAMINE, NOREPINEPHRINE AND 5-HYDROXYTRYPTAMINE ON THE CAROTID-BODY OF THE DOG
EFFECTS OF DOPAMINE, NOREPINEPHRINE AND 5-HYDROXYTRYPTAMINE ON THE CAROTID-BODY OF THE DOG
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DOI：
10.1016/0034-5687(79)90092-6
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发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
HERBERT, DA
中科院分区：
文献类型：
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作者：
BISGARD, GE;MITCHELL, RA;HERBERT, DA
研究了戊巴比妥麻醉犬颈动脉内灌注多巴胺（DA）、去甲肾上腺素（NE）和5-羟色胺（5-HT）对单纤维或少纤维颈动脉化学受体传入神经制剂活性的影响。静脉注射DA的效果也进行了评估。IC注射DA （10 .mu）。g)和（5-HT） (1 .mu。G)持续地产生一阵强烈的活动，随后是一段时间的抑制。icne （20-40 .mu）也有类似的效果。G)注射，但只有45%的注射发生了激发爆发。在88%的IC - NE注射中发现活性抑制。低剂量的三种胺均可抑制化学受体传入活性。高剂量的DA IV(.约。60 .mu。G /kg)产生兴奋后抑郁，而较低剂量(.apprx。21 .mu。G /kg)只产生抑制作用。d-管嘧啶（50-435 .mu）可阻断3种胺的兴奋作用。克/公斤(四)。二氢麦角胺（140 ~ 270 . μ g/kg）可阻断3种胺的抑制作用。氟哌啶醇（50-400 .mu）可特异性阻断DA的抑制作用。克/公斤(四)。DA、NE和5-HT可以通过增加或减少对生理刺激的反应来调节颈动脉体活动。
The effects of bolus intracarotid (IC) infusions of dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) on activity in single or few-fiber carotid chemoreceptor afferent nerve preparations were studied in pentobarbital anesthetized dogs. The effects of IV infusions of DA were also assessed. IC injections of DA (10 .mu.g) and (5-HT) (1 .mu.g) consistently produced a burst of intense activity followed by a period of inhibition. A similar effect was seen with IC NE (20-40 .mu.g) injections, but the burst of excitation occurred in only 45% of the injections. Inhibition of activity was seen in 88% of the IC NE injections. Low IC doses of all 3 amines produced inhibition of chemoreceptor afferent activity. High doses of DA IV (.apprx. 60 .mu.g/kg) produced excitation followed by depression, while lower doses (.apprx. 21 .mu.g/kg) produced only inhibition. The excitatory effects of all 3 amines were blocked by d-tubocurarine (50-435 .mu.g/kg IV). Inhibitory effects of all 3 amines were blocked by dihydroergotamine (140-270 .mu.g/kg). The inhibitory effect produced by DA was specifically blocked by haloperidol (50-400 .mu.g/kg IV). DA, NE and 5-HT can modulate carotid body activity by increasing or decreasing responses to physiologic stimuli.