The role of the melanocortin-3 receptor in cachexia
The role of the melanocortin-3 receptor in cachexia
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DOI：
10.1111/j.1749-6632.2003.tb03188.x
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Cone, RD
中科院分区：
文献类型：
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作者：
Marks, DL;Cone, RD
恶病质是指食欲急剧下降与脂肪和瘦体重代谢增加的协同组合。这种组合存在于许多慢性疾病中，是死亡率的一个重要决定因素。在本文中，我们提供的证据表明，在急性和慢性疾病模型中，MC 4-R的阻断导致恶病质的急剧减弱。我们还证明了黑皮质素-3受体（MC 3-R）的阻断导致疾病相关性恶病质的增强。最终，这项工作可能会导致对这一广泛的医学问题的药物治疗的调查。
Cachexia refers to a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass. This combination is found in a number of chronic diseases and is an important determinant of mortality. In this paper, we provide evidence that in both acute and chronic disease models, blockade of the MC4-R results in a dramatic attenuation of cachexia. We have also demonstrated that blockade of the melanocortin-3 receptor (MC3-R) leads to enhanced disease-associated cachexia. Ultimately, this work may lead to investigation of drug therapy for this widespread medical problem.