Regulation and roles of Ca2+ stores in human sperm.
Regulation and roles of Ca2+ stores in human sperm.
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DOI：
10.1530/rep-15-0102
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Publicover S
中科院分区：
文献类型：
--
作者：
Correia J;Michelangeli F;Publicover S
[Ca2+]i信号传导是精子功能的关键调节机制。在哺乳动物精子中，Ca2 +渗透性质膜离子通道CatSper是[Ca2 +]i信号传导的中心，但有充分的证据表明，细胞内细胞器中储存的Ca2 +在功能上也很重要。在这里，我们简要回顾了目前的理解的多样性的Ca2 +商店和调节其活动的机制。然后，我们考虑的证据参与这些商店在[Ca2 +]i信号在哺乳动物（主要是人类）精子，激动剂，可以激活这些商店和它们的作用，控制精子功能。最后，我们考虑的证据表明，膜Ca2 +通道和存储的Ca2 +可能发挥离散的作用，在精子活动的调节，并提出了一种机制，这些不同的组件的精子Ca2 +信号装置可能相互作用，产生复杂的和空间多样的[Ca2 +]i信号。
[Ca2 +]i signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca2 +-permeable plasma membrane ion channel CatSper is central to [Ca2 +]i signalling, but there is good evidence that Ca2 + stored in intracellular organelles is also functionally important. Here we briefly review the current understanding of the diversity of Ca2 + stores and the mechanisms for the regulation of their activity. We then consider the evidence for the involvement of these stores in [Ca2 +]i signalling in mammalian (primarily human) sperm, the agonists that may activate these stores and their role in control of sperm function. Finally we consider the evidence that membrane Ca2 + channels and stored Ca2 + may play discrete roles in the regulation of sperm activities and propose a mechanism by which these different components of the sperm Ca2 +-signalling apparatus may interact to generate complex and spatially diverse [Ca2 +]i signals.
影响因子：
2.6
作者：
Chandrashekran A;Isa I;Dudhia J;Thrasher AJ;Dibb N;Casimir C;Readhead C;Winston R
通讯作者：
Winston R