Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: Deficits induced by scopolamine and by prolonging the retention interval
Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: Deficits induced by scopolamine and by prolonging the retention interval
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DOI：
10.1016/j.pbb.2006.08.007
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发表时间：
2006-09-01
影响因子：
3.6
通讯作者：
Pouzet, Bruno
中科院分区：
文献类型：
--
作者：
de Bruin, Natasja;Pouzet, Bruno
已经发现在几种神经精神疾病中情节记忆受损。由Ennaceur和Delacour [Ennaceur A.，Delacour J.大鼠记忆神经生物学研究的一种新的一次性试验：1。行为数据。Behav Brain Res 1988; 31：47-59.]，是一种测量大鼠和小鼠特定形式情景记忆的方法。它基于啮齿动物的自发行为，可以被认为是完全不含参考记忆成分的保持测试。因此，ORT已越来越多地被用来作为一种实验工具，在评估药物对记忆的影响，并调查学习和记忆的神经机制，在本研究中，主要目标是评估加兰他敏在瑞士小鼠在ORT对东莨菪碱诱导的赤字和不同的保留间隔的影响。小鼠在15 min的保留试验间隔（ITI）时具有良好的物体识别记忆。在较长的时间间隔（1小时，4小时和24小时）的对象的歧视是不存在的。加兰他敏（10 mg/kg，皮下给药，采集前30分钟）部分逆转东莨菪碱（0.63 mg/kg，皮下给药，采集前30分钟），并将性能标准化为对照水平。当使用两种不同的保留间隔（15分钟和1小时）时，还研究了较低剂量的加兰他敏（0.63 mg/kg）。加兰他敏（0.63 mg/kg）无不良反应。溶剂处理的小鼠在1小时ITI条件下不能区分新的和熟悉的物体（辨别指数等于零），而加兰他敏（0.63 mg/kg）处理的小鼠获得了良好的物体识别记忆性能。东莨菪碱诱导的缺陷，当使用较长的保留时间间隔。(c)2006年爱思唯尔公司All rights reserved.
Episodic memory has been found to be impaired in several neuropsychiatric disorders. The object recognition task (ORT), introduced by Ennaceur and Delacour [Ennaceur A., Delacour J. A new one-trial test for neurobiological studies of memory in rats: 1. Behavioral data. Behav Brain Res 1988; 31: 47-59.], is a method to measure a specific form of episodic memory in rats and mice. It is based on the spontaneous behavior of rodents and can be considered as a retention test completely free of reference memory components. Therefore, the ORT has been increasingly used as an experimental tool in assessing drug effects on memory and investigating the neural mechanisms underlying learning and memory.In the present study, the main goal was to evaluate the effects of galantamine in Swiss mice in the ORT on scopolamine-induced deficits and with different retention intervals. Mice had a good object recognition memory at the 15 min retention intertrial interval (ITI). Object discrimination was absent at the longer intervals (1 h, 4 h and 24 h). Galantamine (10 mg/kg, administered s.c., 30 min prior to acquisition) partially reversed effects of scopolamine (0.63 mg/kg, administered s.c., 30 min prior to acquisition) and normalized performance to control levels. A lower dose of galantamine (0.63 mg/kg) was also investigated when two different retention intervals (15 min and I h) were used. Galantamine (0.63 mg/kg) had no adverse effects. Solvent-treated mice in the 1 h ITI condition did not discriminate between the novel and the familiar object (discrimination index was equal to zero), while galantamine (0.63 mg/kg)-treated mice attained a good object recognition memory performance.In conclusion, galantamine was shown to possess memory-enhancing effects in two conditions that reduced object discrimination: scopolamine-induced deficits and when a longer retention interval was used. (c) 2006 Elsevier Inc. All rights reserved.