Antiviral screening of British Columbian medicinal plants
Antiviral screening of British Columbian medicinal plants
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DOI：
10.1016/0378-8741(95)90037-3
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发表时间：
1995-12-01
影响因子：
5.4
通讯作者：
Towers, GHN
中科院分区：
文献类型：
--
作者：
McCutcheon, AR;Roberts, TE;Towers, GHN
对一百种甲醇植物提取物进行了筛选，以确定其对七种病毒的抗病毒活性。发现12种浸提液在测试的非细胞毒性浓度下具有抗病毒活性。蔷薇科植物山刺玫和唐菖蒲的提取物对肠道冠状病毒具有很强的抗病毒活性。另一种蔷薇科植物Potentilla prostitta的根提取物完全抑制呼吸道合胞病毒。总状接骨木分支尖端提取物对呼吸道合胞病毒也非常有效，而刺人参的内树皮提取物部分抑制该病毒。结果表明，Ipomopsis aggregata提取物对副流感病毒3型有很好的抗病毒活性，Lomatium dissectum根提取物对轮状病毒的致细胞病变作用有完全的抑制作用。此外，角叶碎米荠、锥头草、美洲赖草、水龙骨和毛蕊花等植物提取物对疱疹病毒1型也有一定的抗病毒活性。
One hundred methanolic plant extracts were screened for antiviral activity against seven viruses. Twelve extracts were found to have antiviral activity at the non-cytotoxic concentrations tested. The extracts of Rosa nutkana and Amelanchier alnifolia, both members of the Rosaceae, were very active against an enteric coronavirus. A root extract of another member of the Rosaceae, Potentilla arguta, completely inhibited respiratory syncytial virus. A Sambucus racemosa branch tip extract was also very active against respiratory syncytial virus while the inner bark extract of; Oplopanax horridus partially inhibited this virus. An extract of Ipomopsis aggregata demonstrated very good activity against parainfluenza virus type 3, A Lomatium dissectum root extract completely inhibited the cytopathic effects of rotavirus, In addition to these, extracts prepared from the following plants exhibited antiviral activity against herpesvirus type 1: Cardamine angulata, Conocephalum conicum, Lysichiton americanum, Polypodium glycyrrhiza and Verbascum thapsus.