Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity
Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity
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DOI：
10.1016/j.neulet.2013.08.062
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发表时间：
2013-10-25
影响因子：
2.5
通讯作者：
Deumens, Ronald
中科院分区：
文献类型：
--
作者：
Leinders, Mathias;Knaepen, Liesbeth;Deumens, Ronald
脊髓小胶质细胞活化在周围神经损伤后神经病理性疼痛的发展中起重要作用。我们在这里提供的证据表明，在L5脊神经横断的同侧腰背角的小胶质细胞标志物Iba-1的表达升高，持续至少14周，在此时间机械超敏反应已完全解决。然而，Iba-1表达显著低于4周时。因此，我们的结论是，小胶质细胞仍然部分激活超出阶段的疼痛超敏反应。因此，小胶质细胞和神经病理性疼痛结果之间的关系在神经损伤后随时间而变化。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Spinal microglial activation plays a major role in the development of neuropathic pain following peripheral nerve injury. We here provide evidence for an elevated expression of the microglial marker Iba-1 in the lumbar dorsal horn ipsilateral to L5 spinal nerve transection that persists for at least 14 weeks, a time at which mechanical hypersensitivity had fully resolved. Iba-1 expression was, however; significantly lower than at 4 weeks. We therefore conclude that microglia remain partly activated beyond the phase of pain hypersensitivity. Thus, the relation between microglial cells and neuropathic pain outcome is subject to change over time after nerve injury. (C) 2013 Elsevier Ireland Ltd. All rights reserved.