Comorbid conditions and health-related quality of life in long-term cancer survivorsassociations with demographic and medical characteristics
Comorbid conditions and health-related quality of life in long-term cancer survivorsassociations with demographic and medical characteristics
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DOI：
10.1007/s11764-018-0708-6
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发表时间：
2018-10-01
影响因子：
3.7
通讯作者：
Mehnert, Anja
中科院分区：
文献类型：
--
作者：
Goetze, Heide;Taubenheim, Sabine;Mehnert, Anja
目的我们的研究详细概述了长期癌症幸存者的共病状况和与健康相关的生活质量，并分析了人口统计学、疾病和治疗相关特征的影响。方法我们在一项横断面研究中展示了从混合肿瘤实体的 1000 名幸存者在癌症诊断后 5 年和 10 年获得的数据。我们使用 EORTC QLQ-C30 与一般人群的性别和年龄匹配参考值进行比较，通过自我报告和健康相关生活质量来分析身体症状和健康状况的患病率。结果癌症幸存者平均报告 5 种合并症； 23% 患有 7 种或更多合并症。癌症幸存者报告的身体症状负担比普通人群更高，尤其是疲劳、失眠和疼痛。长期和迟发效应的类型和发生率因疾病相关因素（例如癌症类型、治疗）和患者特征而异。癌症幸存者的生活质量也低于普通人群，特别是在日常活动、社交生活、心理健康和经济困难方面。高质量的生活和低发病率之间存在正相关关系。结论关于各种癌症对身体的长期影响的具体知识可以提高医疗保健专业人员对高危患者的认识，并有助于制定适当的预防和生存计划。对癌症幸存者的影响心理健康领域的局限性强调了心理肿瘤生存护理计划的重要性，该计划超出了康复时间。在长期随访护理中应特别关注患者的经济状况。
PurposeOur study provides a detailed overview of comorbid conditions and health-related quality of life of long-term cancer survivors and analyses the impact of demographic, disease- and treatment-related characteristics.MethodsWe present data obtained from 1000 survivors across mixed tumour entities 5 and 10years after cancer diagnosis in a cross-sectional study. We analyse the prevalence of physical symptoms and health conditions via self-report and health-related quality of life using the EORTC QLQ-C30 in comparison to gender- and age-matched reference values of the general population.ResultsCancer survivors reported on average 5 comorbidities; 23% had 7 or more comorbid conditions. Cancer survivors reported higher physical symptom burden than the populationespecially fatigue, insomnia and pain. Type and prevalence of long-term and late effects differ with disease-related factors (e.g. cancer type, treatment) and characteristics of the patient. Cancer survivors also reported lower quality of life than the population, especially in everyday activities, social life, psychological well-being and financial difficulties. There was a positive association between high quality of life and a low level of morbidity.ConclusionsThe specific knowledge about physical long-term consequences for the individual types of cancer could raise awareness in health care professionals for high-risk patients and help to develop adequate prevention and survivorship-programs.Implications for Cancer survivorsLimitations in the mental health areaunderlines the importance of psycho-oncological survivorship-care-plans, which go beyond the time of rehabilitation. Special attention should be given to the financial situation of patients in long-term follow-up care.