Extracellular matrix in cancer progression and therapy.
Extracellular matrix in cancer progression and therapy.
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DOI：
10.1515/mr-2021-0028
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发表时间：
2022-04
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近年来，具有异质性细胞组成和肿瘤微环境的肿瘤生态系统日益成为肿瘤研究的热点。细胞外基质（ECM），肿瘤微环境的主要组成部分，以及它与肿瘤细胞和基质细胞的相互作用也受到了极大的关注。与肿瘤微环境的其他组分一样，实体瘤中的ECM与正常器官和组织中的ECM显著不同。本文综述了近年来有关肿瘤细胞外基质在肿瘤发生、生长、血管生成和侵袭过程中的作用。我们强调ECM和细胞之间的生物分子，生物物理和机械化学相互作用不仅调节癌症进展的步骤，而且影响全身癌症治疗的疗效。我们进一步讨论了靶向和修饰肿瘤ECM以改善癌症治疗的策略。
The tumor ecosystem with heterogeneous cellular compositions and the tumor microenvironment has increasingly become the focus of cancer research in recent years. The extracellular matrix (ECM), the major component of the tumor microenvironment, and its interactions with the tumor cells and stromal cells have also enjoyed tremendously increased attention. Like the other components of the tumor microenvironment, the ECM in solid tumors differs significantly from that in normal organs and tissues. We review recent studies of the complex roles the tumor ECM plays in cancer progression, from tumor initiation, growth to angiogenesis and invasion. We highlight that the biomolecular, biophysical, and mechanochemical interactions between the ECM and cells not only regulate the steps of cancer progression, but also affect the efficacy of systemic cancer treatment. We further discuss the strategies to target and modify the tumor ECM to improve cancer therapy.