Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain: a didactic review.
Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain: a didactic review.
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DOI：
10.1097/rmr.0b013e31821e568f
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Alger JR
中科院分区：
文献类型：
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作者：
Alger JR
本文介绍了有关的背景信息，估计脑代谢物浓度的方法，从磁共振波谱（MRS）和磁共振波谱成像（MRSI）测量活人脑组织。报告审查了与这一方法有关的进展，重点是过去十年报告的进展。它是为放射科医生和MRI技术人员组成的目标受众编写的。它概括地描述了MRS信号幅度和浓度之间的关系。然后，它提出了一个概述的许多实际问题与推导浓度仅从绝对测量信号幅度，并演示了如何可以成功地使用各种信号校准方法。积分信号幅度的概念与示例，有助于定性阅读的MRS数据，以及理解用于定量测量的方法。提出了与准确测量脑谱中具有来自其他代谢物的重叠信号和来自水和脂质的重叠干扰信号的个体信号幅度相关联的问题。总结了目前用最小二乘拟合软件获得准确振幅估计的方法。
This article presents background information related to methodology for estimating brain metabolite concentration from Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Spectroscopic Imaging (MRSI) measurements of living human brain tissue. It reviews progress related to this methodology with emphasis placed on progress reported during the past ten years. It is written for a target audience composed of radiologists and MRI technologists. It describes in general terms the relationship between MRS signal amplitude and concentration. It then presents an overview of the many practical problems associated with deriving concentration solely from absolute measured signal amplitudes and demonstrates how a various signal calibration approaches can be successfully used. The concept of integrated signal amplitude is presented with examples that are helpful for qualitative reading of MRS data as well as for understanding the methodology used for quantitative measurements. The problems associated with the accurate measurement of individual signal amplitudes in brain spectra having overlapping signals from other metabolites and overlapping nuisance signals from water and lipid is presented. Current approaches to obtaining accurate amplitude estimates with least squares fitting software are summarized.