INVOLVEMENT OF COMPLEMENT IN PSORIASIS AND ATOPIC-DERMATITIS - MEASUREMENT OF C3A AND C5A, C-3, C-4 AND C1 INACTIVATOR
INVOLVEMENT OF COMPLEMENT IN PSORIASIS AND ATOPIC-DERMATITIS - MEASUREMENT OF C3A AND C5A, C-3, C-4 AND C1 INACTIVATOR
复制标题
DOI：
10.1007/bf00509233
复制
发表时间：
1985-01-01
影响因子：
3
通讯作者：
SCHOPF, E
中科院分区：
文献类型：
--
作者：
KAPP, A;WOKALEK, H;SCHOPF, E
对35例特应性皮炎（AD）和24例银屑病患者的外周血进行了正常补体[C]成分和活化产物的测定。没有患者在采血前6周接受全身或局部类固醇治疗。采用放射免疫扩散法测定血清中C3、C4和C1灭活剂（C1 INA）水平，放射免疫法测定C3 a和C5 a水平。与健康的非特应性对照相比，发现C3、C4和C1 INA的水平在两种疾病中显著增加。在寻常型银屑病和点滴型银屑病患者之间未检测到实质性差异，这表明所发现的差异不是由于先前或伴随感染所致。在AD中，C3 a水平有升高的趋势;在银屑病中，C3 a水平显著升高。在这两种疾病中，都没有检测到可测量的C5 a。在AD和银屑病中，补体明显参与炎症过程。升高的C3 a水平表明存在补体系统的持续激活，导致炎症介质的产生。
Normal complement [C] components and activation products were determined in the peripheral blood of 35 patients with atopic dermatitis (AD) and 24 patients with psoriasis at a mild to intermediate stage. No patients received systemic or local steroid therapy 6 wk prior to blood collection. Levels of C3, C4 and C1 inactivator (C1 INA) were determined in serum by radial immunodiffusion; C3a and C5a levels were measured by radioimmunoassay. In comparison to healthy nonatopic controls, the levels of C3, C4 and C1 INA were found to be significantly increased in both diseases. No substantial differences were detected between patients with psoriasis vulgaris and psoriasis guttata, which suggests that the dissimilarities found were not due to preceding or concomitant infections. In AD, there was a tendency towards increased C3a levels; in psoriasis, C3a levels were significantly increased. In both diseases, no measurable amounts of C5a could be detected. In AD and psoriasis, the complement evidently participates in the inflammatory process. Elevated levels of C3a suggest that there is a continuous activation of the complement system leading to the generation of inflammatory mediators.