Mapping functional connectivity in patients with brain lesions
Mapping functional connectivity in patients with brain lesions
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DOI：
10.1002/ana.21224
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发表时间：
2008-02-01
影响因子：
11.2
通讯作者：
Nagarajan, Srikantan S.
中科院分区：
文献类型：
--
作者：
Guggisberg, Adrian G.;Honma, Susanne M.;Nagarajan, Srikantan S.
目的：脑区之间的功能连接的空间分布和局灶性脑损伤引起的干扰知之甚少。基于受损脑组织与健康区域之间的生理相互作用脱节的原理，本研究旨在根据大脑区域与其他区域的连通性来绘制大脑区域的功能。方法：从连续15例局灶性脑损伤患者和14名健康对照者中获得静息状态下自发皮质活动的脑磁图记录。使用自适应空间滤波技术估计大脑中的神经活动。脑体素之间的平均想象的连贯性，然后计算作为一个指数的功能connections.Results：想象的连贯性是最大的α频率范围内对应于人类皮质空转节奏。在健康的受试者中，功能关键的大脑区域，如体感和语言皮层，具有最高的阿尔法相干性。当与健康对照受试者相比时，所有病变患者都有弥漫性或分散性脑区，α相干性降低。与完整的对侧区域相比，病变引起的神经功能缺损患者相应脑区的连通性估计值降低。在术前无神经功能缺损的肿瘤患者中，显示连贯性降低的脑区可以通过手术切除，而不会发生术后缺损。用脑磁图测量的静息状态相干性能够映射大脑的功能连接，因此可以提供有价值的信息，用于规划脑病变患者的切除手术，以及对健康受试者的结构-功能关系的研究。
Objective: The spatial distribution of functional Connectivity between brain areas and the disturbance introduced by focal brain lesions are poorly understood. Based on the rationale that damaged brain tissue is disconnected from the physiological interactions among healthy areas, this study aimed to map the functionality of brain areas according to their connectivity with other areas.Methods: Magnetoencephalography recordings of spontaneous cortical activity during resting state were obtained from 15 consecutive patients with focal brain lesions and from 14 healthy control subjects. Neural activity in the brain was estimated using an adaptive spatial filtering technique. The mean imaginary coherence between brain voxels was then calculated as an index of functional connectivity.Results: Imaginary coherence was greatest in the alpha frequency range corresponding to the human cortical idling rhythm. In healthy subjects, functionally critical brain areas such as the somatosensory and language cortices had the highest alpha coherence. When compared with healthy control subjects, all lesion patients had diffuse or scattered brain areas with decreased alpha coherence. Patients with lesion-induced neurological deficits displayed decreased connectivity estimates in the corresponding brain area compared with intact contralateral regions. In tumor patients without preoperative neurological deficits, brain areas showing decreased coherence could be surgically resected without the occurrence of postoperative deficits.Interpretation: Resting state coherence measured with magnetoencephalography is capable of mapping the functional connectivity of the brain, and can therefore offer valuable information for use in planning resective surgeries in patients with brain lesions, as well as investigations into structural-functional relationships in healthy subjects.