On the stability of ascorbic acid in emulsified systems for topical and cosmetic use
On the stability of ascorbic acid in emulsified systems for topical and cosmetic use
复制标题
DOI：
10.1016/s0378-5173(99)00228-8
复制
发表时间：
1999-10-25
影响因子：
5.8
通讯作者：
Bovo, S
中科院分区：
文献类型：
--
作者：
Gallarate, M;Carlotti, ME;Bovo, S
使用非离子型、非乙氧基化、皮肤相容性乳化剂制备了几种O/W微乳液、O/W和W/O乳液以及W/O/W多重乳液。将抗坏血酸（维生素C）添加到乳化体系中，并在有氧条件下在45.0 ℃下研究其抗氧化稳定性，并与不同pH值的水溶液中的抗氧化稳定性进行比较。所有的乳化系统提供保护，抗坏血酸，其降解速率，随着pH值的增加而增加，在乳化系统中比在水溶液中慢。抗坏血酸的最高保护是当它溶解在W/O/W多重乳液的内部水相中时，在45和20 ℃下长期储存。一个伪一级机制被假设为抗坏血酸降解的实验条件下，只要丰富的溶解氧存在。(C)1999 Elsevier Science B. V.保留所有权利。
Several O/W microemulsions, O/W and W/O emulsions and a W/O/W multiple emulsion were prepared using non-ionic, non-ethoxylated, skin compatible emulsifiers. Ascorbic acid (vitamin C) was added to the emulsified systems and its stability against oxidation was studied at 45.0 degrees C in aerobic conditions and compared with that in aqueous solutions at different pH values. All emulsified systems provided protection to ascorbic acid, as its degradation rate, which increased with increasing pH, was slower in emulsified systems than in aqueous solutions. The highest protection of ascorbic acid was when it was dissolved in the inner aqueous phase of the W/O/W multiple emulsion, both at 45 and at 20 degrees C for long storage. A pseudo first-order mechanism was hypothesised for ascorbic acid degradation in the experimental conditions for as long as abundant dissolved oxygen was present. (C) 1999 Elsevier Science B.V. All rights reserved.