A cost-effective monitoring technique in particle therapy via uncollimated prompt gamma peak integration
A cost-effective monitoring technique in particle therapy via uncollimated prompt gamma peak integration
复制标题
DOI：
10.1063/1.4980103
复制
发表时间：
2017-04-10
影响因子：
4
通讯作者：
Zoccarato, Y.
中科院分区：
文献类型：
--
作者：
Krimmer, J.;Angellier, G.;Zoccarato, Y.
为了检测粒子治疗过程中与规定治疗的偏差，研究了未准直的瞬发γ射线时间分布的积分。其目的是通过简单且具有成本效益的设置提供信息，独立于束线的监测设备。用65 MeV质子在临床回旋加速器上进行了测量。从目标发射的瞬发伽马射线通过飞行时间来识别。PMMA靶内的质子范围已通过调制器轮改变。作为调制器位置的函数的瞬发伽马峰值积分的测量变化与模拟一致。探测器覆盖25 msr的立体角（对应于3-4 in.的直径）。在离束轴50厘米的距离处）和10（8）个入射质子，可以检测到瞬发伽马射线计数率的百分之几的偏差。对于本配置，计数率的这种变化对应于PMMA靶中质子范围的3 mm变化。此外，模拟研究表明，来自多个检测器的信号的组合可以用于检测目标的错位。这些信号的不同组合导致检测到的瞬发伽马射线的精确数量，这与实际目标位置无关。出版社：AIP Publishing
For the purpose of detecting deviations from the prescribed treatment during particle therapy, the integrals of uncollimated prompt gamma-ray timing distributions are investigated. The intention is to provide information, with a simple and cost-effective setup, independent from monitoring devices of the beamline. Measurements have been performed with 65MeV protons at a clinical cyclotron. Prompt gamma-rays emitted from the target are identified by means of time-of-flight. The proton range inside the PMMA target has been varied via a modulator wheel. The measured variation of the prompt gamma peak integrals as a function of the modulator position is consistent with simulations. With detectors covering a solid angle of 25 msr (corresponding to a diameter of 3-4 in. at a distance of 50 cm from the beam axis) and 10(8) incident protons, deviations of a few per cent in the prompt gamma-ray count rate can be detected. For the present configuration, this change in the count rate corresponds to a 3mm change in the proton range in a PMMA target. Furthermore, simulation studies show that a combination of the signals from multiple detectors may be used to detect a misplacement of the target. A different combination of these signals results in a precise number of the detected prompt gamma rays, which is independent on the actual target position. Published by AIP Publishing.