Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic
Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic
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DOI：
10.1038/sj.mp.4000721
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发表时间：
2000-07-01
影响因子：
11
通讯作者：
Gershon, S
中科院分区：
文献类型：
--
作者：
Antelman, SM;Levine, J;Gershon, S
这篇综述从生物学和临床两方面对时间依赖性致敏（TDS）进行了综述，TDS是一种对威胁的古老的放大记忆反应，表现在药物和非药物应激源诱导神经元和行为效应的能力上，这种效应在单次或急性暴露后随着时间的推移而增强。有证据表明，TDS可能参与了一系列疾病的发展，以及基于TDS原则的药物方案如何为治疗精神疾病和其他疾病提供一种新颖和革命性的手段。
This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could provide a novel and revolutionary means of treating psychiatric and other illnesses.