REGENERATION OF SEVERED NERVE FIBERS IN THE SPINAL CORD OF THE ADULT CAT
REGENERATION OF SEVERED NERVE FIBERS IN THE SPINAL CORD OF THE ADULT CAT
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DOI：
10.1002/cne.901010304
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发表时间：
1954-01-01
影响因子：
2.5
通讯作者：
WINDLE, WF
中科院分区：
文献类型：
--
作者：
CLEMENTE, CD;WINDLE, WF
79 只成年猫的脊髓被横断，其中 31 只作为对照，其他猫接受 Piromen 或 ACTH 治疗几天到 19 个月。在接受 Piromen 治疗的动物中，脊髓切断端立即形成的软脑膜神经胶质膜未能形成。与未治疗的脊髓动物相比，病变区域血管更多，含有更多的中性细胞和巨噬细胞，持续时间更长，并且取代出血的胶原结缔组织密度较低。在缺乏软脑膜神经胶质膜的情况下，松散的髓外纤维结缔组织似乎与脊髓实质融合。对照组和治疗组动物的脊髓内神经元变性和早期再生相似。术后 15 天或更长时间，发芽的神经纤维到达横断处，但在对照组中，遇到了软脑膜胶质膜，返回并停止生长。在接受治疗的脊髓猫中，神经元芽穿过病变处疏松组织的网状结构。再生的成功取决于脐带残端并置的紧密程度。小于2毫米的间隙由一些神经纤维束和束桥接。在超过 2 毫米的间隙中，再生的椎管内神经元穿过纤维结缔组织，但很少有神经元似乎完全穿过病变部位。
Spinal cords were transected in 79 adult cats, 31 serving as controls and the others receiving Piromen or ACTH for periods of a few days to 19 months. Pia-glial membranes, which immediately developed over the cut ends of the spinal cord, failed to form in the Piromen-treated animals. The lesion area was more vascular, contained more indifferent cells and macrophages for longer periods, and the collagenous connective tissue replacing hemorrhage was less dense than in the non-treated spinal animals. In the absence of pia-glial membranes, loose extramedullary fibrous connective tissue appeared to blend with the spinal cord parenchyma. Degeneration and early regeneration of intraspinal neurons were similar in control and treated animals. Sprouting nerve fibers reached the transection 15 days or more after operation, but in controls encountered pia-glial membranes, turned back, and ceased growing. In the treated spinal cats, neuron sprouts made their way through the reticulum of loose tissue in the lesion. Success of regeneration depended upon closeness of apposition of the cord stumps. Gaps of less than 2 mm were bridged by some fascicles and tracts of nerve fibers. In gaps of more than 2 mm, regenerating intraspinal neurons were followed through the fibrous connective tissue, but few appeared to completely traverse the lesion.