Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis.
Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis.
复制标题
红细胞在毛细血管后扩张中启动白细胞滚动：格子玻尔兹曼分析。
DOI：
10.1016/s0006-3495(03)74467-1
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Munn,LanceL
中科院分区：
文献类型：
--
作者：
Sun,Chenghai;Migliorini,Cristiano;Munn,LanceL
白细胞在血管内皮上滚动需要血液中循环的白细胞与血管壁之间的初始接触。尽管特定的粘附机制涉及白细胞-内皮相互作用，但体内粘附模式表明其他流变机制也发挥了作用。先前的研究提出，毛细血管后微静脉中大量白细胞滚动是由于红细胞（RBC）和白细胞进入毛细血管后扩张时之间的相互作用造成的，但流体动力学的细节尚未阐明。我们使用格子玻尔兹曼方法分析了红细胞和白细胞从毛细血管流入毛细血管后微静脉时的相互作用。该技术提供了流场的完整解决方案以及相关几何形状中粒子-粒子力的量化。我们的结果表明，毛细血管-毛细血管后微静脉直径比、红细胞构型和红细胞形状是毛细血管后微静脉中细胞滚动起始的关键决定因素。该模型预测，需要尾随红细胞的最佳配置才能将白细胞推向墙壁。
Leukocyte rolling on the vascular endothelium requires initial contact between leukocytes circulating in the blood and the vessel wall. Although specific adhesion mechanisms are involved in leukocyte-endothelium interactions, adhesion patterns in vivo suggest other rheological mechanisms also play a role. Previous studies have proposed that the abundance of leukocyte rolling in postcapillary venules is due to interactions between red blood cells (RBCs) and leukocytes as they enter postcapillary expansions, but the details of the fluid dynamics have not been elucidated. We have analyzed the interactions of red and white blood cells as they flow from a capillary into a postcapillary venule using a lattice Boltzmann approach. This technique provides the complete solution of the flow field and quantification of the particle-particle forces in a relevant geometry. Our results show that capillary-postcapillary venule diameter ratio, RBC configuration, and RBC shape are critical determinants of the initiation of cell rolling in postcapillary venules. The model predicts that an optimal configuration of the trailing red blood cells is required to drive the white blood cell to the wall.