Tying Metabolic Branches With Histone Tails Using Systems Biology
Tying Metabolic Branches With Histone Tails Using Systems Biology
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DOI：
10.1177/2516865719869683
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发表时间：
2019-08-01
影响因子：
2.2
通讯作者：
Chandrasekaran, Sriram
中科院分区：
文献类型：
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作者：
Chandrasekaran, Sriram
组蛋白修饰代表了将营养状态与基因表达联系起来的先天细胞机制。甲硫氨酸如乙酰辅酶A和S-腺苷甲硫氨酸通过作为修饰组蛋白的底物来影响基因表达。然而，我们缺乏基于细胞代谢状态确定组蛋白修饰水平的预测模型。与组蛋白标记交叉的众多代谢途径使得理解它们的相互依赖性具有高度挑战性。在这里，我们强调新的系统生物学工具，以解开营养线索和代谢通量对组蛋白修饰的影响。
Histone modifications represent an innate cellular mechanism to link nutritional status to gene expression. Metabolites such as acetyl-CoA and S-adenosyl methionine influence gene expression by serving as substrates for modification of histones. Yet, we lack a predictive model for determining histone modification levels based on cellular metabolic state. The numerous metabolic pathways that intersect with histone marks makes it highly challenging to understand their interdependencies. Here, we highlight new systems biology tools to unravel the impact of nutritional cues and metabolic fluxes on histone modifications.