Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood
Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood
复制标题
早年经历中国饥荒与成年后代谢综合征风险的关系
DOI：
10.1159/000507356
复制
发表时间：
2020-06-01
影响因子：
3.9
通讯作者：
Chen, Yongjie
中科院分区：
文献类型：
--
作者：
Peng, Yue;Hai, Miaomiao;Chen, Yongjie
目的：探讨中国成年人早期饥饿暴露与代谢综合征（MS）风险的关系。方法：数据来源于2009年中国健康与营养调查。当出现以下3项或3项以上时，即为MS：（1）男性腰围>90 cm或女性腰围>85 cm;（2）空腹血糖≥6.1 mmol/L;（3）收缩压≥130 mm Hg/代谢性血压≥85 mm Hg;（4）空腹甘油三酯≥1.70 mmol/L;（5）高密度脂蛋白胆固醇<1.04 mmol/L。所有参与者被分为5组：1961年以后出生的无暴露; 1959年至1961年的胎儿期暴露; 1956年至1958年的幼儿期暴露; 1953年至1955年的中期暴露; 1949年至1952年的晚期暴露。本研究共纳入2，080例受试者。结果如下：在农村，胎儿期和幼儿期的饥饿暴露与MS的低风险相关（p = 0.0491和0.0245; OR 0.583和0.703; OR，95%CI分别为0.341-0.998和0.517-0.956）。但儿童晚期的饥饿暴露与MS的高风险相关（p = 0.0140; OR 3.096;和OR，95%CI 1.257-7.625）。儿童早期饥饿暴露与男性MS风险较低相关（p = 0.0120; OR 0.633;和OR，95%CI 0.443-0.904）。结论：在儿童中期和晚期的饥荒暴露与MS的风险较高，特别是在农村，男性和严重饥荒地区。
Objective: To explore the association of famine exposure in early life with the risk of metabolic syndrome (MS) in the Chinese adults. Methods: Data were obtained from the wave 2009 of the China Health and Nutrition Survey. MS was identified when 3 or more of the following components happened: (1) waist circumference >90 cm in males or >85 cm in females; (2) fasting glucose ≥6.1 mmol/L; (3) systolic blood pressure ≥130 mm Hg/diabolic blood pressure ≥85 mm Hg; (4) fasting triglyceride ≥1.70 mmol/L; and (5) high-density lipids cholesterol <1.04 mmol/L. All participants were divided into 5 groups: no exposure, born after 1961; fetal life exposure, between 1959 and 1961; early childhood exposure, between 1956 and 1958; mid-childhood exposure, between 1953 and 1955; and late childhood exposure, between 1949 and 1952. A total of 2,080 subjects were included in this study. Results: In rural, famine exposure in fetal life and early childhood was associated with the lower risk of MS (p = 0.0491 and 0.0245; OR 0.583 and 0.703; and OR, 95% CI 0.341–0.998 and 0.517–0.956, respectively). But famine exposure in late childhood was associated with the higher risk of MS (p = 0.0140; OR 3.096; and OR, 95% CI 1.257–7.625). Famine exposure in early childhood was associated with the lower risk of MS (p = 0.0120; OR 0.633; and OR, 95% CI 0.443–0.904) in males. Conclusions: Famine exposure in mid- and late-childhood was associated with the higher risk of MS, especially in rural, males, and severe famine areas.