CHOLESTYRAMINE PROMOTES RECEPTOR-MEDIATED LOW-DENSITY-LIPOPROTEIN CATABOLISM
CHOLESTYRAMINE PROMOTES RECEPTOR-MEDIATED LOW-DENSITY-LIPOPROTEIN CATABOLISM
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DOI：
10.1056/nejm198005293022202
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发表时间：
1980-01-01
影响因子：
158.5
通讯作者：
MORGAN, HG
中科院分区：
文献类型：
--
作者：
SHEPHERD, J;PACKARD, CJ;MORGAN, HG
在 5 名患有杂合子家族性高胆固醇血症的女性中研究了考来烯胺（24 g/天）对受体介导和受体非依赖性低密度脂蛋白分解代谢的影响。考来烯胺通过受体途径使循环低密度脂蛋白脱辅基蛋白的清除分数加倍（P < 0.01），从而降低循环低密度脂蛋白脱辅基蛋白的水平，但通过不依赖受体途径的分解代谢分数保持不变。脱辅基蛋白分解代谢的绝对速率不受治疗影响，但每个途径处理的量发生了变化。通过生理可控受体途径的分解代谢增加了 71% (P < 0.05)，但通过非受体途径的清除率下降了 12%。数据证明考来烯胺通过其特定的生理清除途径促进低密度脂蛋白分解代谢的效用。当受到适当的刺激时，患有家族性高胆固醇血症的杂合子可以增加其低密度脂蛋白受体的活性。
The influence of cholestyramine (24 g/day) on receptor-mediated and receptor-independent low-density-lipoprotein catabolism was studied in 5 women with heterozygous familial hypercholesterolemia. Cholestyramine lowered the level of circulating low-density-lipoprotein apoprotein by doubling (P < 0.01) its fractional clearance via the receptor path, but fractional catabolism by the receptor-independent route remained unchanged. The absolute rate of catabolism of the apoprotein was not affected by treatment but the amounts handled by each pathway altered. Catabolism via the physiologically controllable receptor route increased by 71% (P < 0.05), but there was a 12% drop in clearance by the nonreceptor pathway. The data demonstrate the utility of cholestyramine in promoting low-density-lipoprotein catabolism via its specific physiologic clearance pathway. Heterozygotes with familial hypercholesterolemia can increase the activity of their low-density-lipoprotein receptors when presented with an appropriate stimulus.