Vascular calcification: pathophysiology and risk factors.
Vascular calcification: pathophysiology and risk factors.
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DOI：
10.1007/s11906-012-0265-8
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发表时间：
2012-06
影响因子：
5.6
通讯作者：
Moe, Sharon M.
中科院分区：
文献类型：
--
作者：
Chen, Neal X.;Moe, Sharon M.
关键词：
血管钙化可发生在几乎所有的动脉床以及中膜层和内膜层。引发因素和临床后果取决于潜在的疾病状态和钙化的位置。最好的研究表现是冠状动脉钙化，部分原因是明显的临床后果，但也因为基于CT的成像方式。在一般人群中，冠状动脉钙化的存在增加了心血管风险，高于传统的Fractionary风险因素预测，表明存在非传统的风险因素。在慢性肾脏病（CKD）患者中，冠状动脉钙化比一般人群更普遍，且明显更严重。在这些CKD患者中，非传统风险因素如氧化应激、晚期糖基化终产物和矿物质代谢紊乱也更普遍和更严重，并为血管钙化的发病机制提供了机制性见解。
Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal layers. The initiating factors and clinical consequences depend on the underlying disease state and the location of the calcification. The best studied manifestation is coronary artery calcification, in part because of the obvious clinical consequences, but also because of CT based imaging modalities. In the general population, the presence of coronary artery calcification increases cardiovascular risk above that predicted by traditional Framingham risk factors, suggesting the presence of non-traditional risk factors. In patients with chronic kidney disease (CKD) coronary artery calcification is more prevalent and markedly more severe than in the general population. In these CKD patients, non-traditional risk factors such as oxidative stress, advanced glycation end-products and disordered mineral metabolism are also more prevalent and more severe and offer mechanistic insight into the pathogenesis of vascular calcification.
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影响因子：
19.6
作者：
Chen, Neal X.;Kircelli, Fatih;Moe, Sharon M.
通讯作者：
Moe, Sharon M.
影响因子：
10.8
作者：
Armstrong, Zachary B.;Boughner, Derek R.;Rogers, Kem A.
通讯作者：
Rogers, Kem A.
影响因子：
6.1
作者：
Chen, Neal X.;Duan, Danxia;Moe, Sharon M.
通讯作者：
Moe, Sharon M.
影响因子：
4.8
作者：
Byon, Chang Hyun;Javed, Amjad;Chen, Yabing
通讯作者：
Chen, Yabing
DOI：
10.1161/atvbaha.107.153668
发表时间：
2007-12-01
影响因子：
8.7
作者：
Al-Aly, Ziyad;Shao, Jian-Su;Towler, Dwight A.
通讯作者：
Towler, Dwight A.