The Regulation of Transcription in Memory Consolidation
The Regulation of Transcription in Memory Consolidation
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DOI：
10.1101/cshperspect.a021741
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发表时间：
2015-01-01
影响因子：
7.2
通讯作者：
Kandel, Eric R.
中科院分区：
文献类型：
--
作者：
Alberini, Cristina M.;Kandel, Eric R.
DNA的从头转录是形成长期记忆的基本要求。在巩固和再巩固，即训练后和激活后阶段，它都需要将记忆状态从脆弱转变为稳定和持久的形式。转录产生的mrna可以翻译成蛋白质，这是新突触连接生长所必需的，而非编码RNA转录物在基因表达中具有调节或效应作用。其结果是一连串的事件，最终导致调节长期记忆储存的神经元发生结构变化。从头转录对突触可塑性和记忆形成至关重要，是由染色质和表观遗传修饰精心安排的。转录调控的复杂性、其时间进程和产生的效应都有助于长期记忆形成的灵活性和持久性。在这篇文章中，我们提供了一个机制的概述，有助于这种转录调节长期记忆的形成。
De novo transcription of DNA is a fundamental requirement for the formation of long-term memory. It is required during both consolidation and reconsolidation, the posttraining and postreactivation phases that change the state of the memory from a fragile into a stable and long-lasting form. Transcription generates both mRNAs that are translated into proteins, which are necessary for the growth of new synaptic connections, as well as noncoding RNA transcripts that have regulatory or effector roles in gene expression. The result is a cascade of events that ultimately leads to structural changes in the neurons that mediate long-term memory storage. The de novo transcription, critical for synaptic plasticity and memory formation, is orchestrated by chromatin and epigenetic modifications. The complexity of transcription regulation, its temporal progression, and the effectors produced all contribute to the flexibilityand persistence of long-term memory formation. In this article, we provide an overview of the mechanisms contributing to this transcriptional regulation underlying long-term memory formation.