The association between different cognitive domains and age in a multi-centre study of middle-aged and older European men
The association between different cognitive domains and age in a multi-centre study of middle-aged and older European men
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DOI：
10.1002/gps.2255
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发表时间：
2009-11-01
影响因子：
4
通讯作者：
Wu, Frederick C. W.
中科院分区：
文献类型：
--
作者：
Lee, David M.;Tajar, Abdelouahid;Wu, Frederick C. W.
我们确定了来自8个欧洲中心的40-79岁社区居住男性（n = 3265）的认知功能水平，并调查了认知表现在不同中心之间的差异程度，不同认知领域与年龄、教育水平、共发病和生活方式因素之间的关系，以及中心和个人因素对认知表现的各自贡献。方法采用视觉建构能力和视觉记忆（Rey-Osterrieth Complex Figure test， ROCF）、地形记忆（Camden地形识别记忆test， CTRM）和处理速度（digital - symbol Substitution test， DSST）三个认知领域进行评估。结果四项认知测试得分均有显著中心间差异。使用多水平线性回归分析（MLRA），年龄、教育程度、抑郁、身体表现和吸烟是认知功能的独立预测因子，这些变量解释了中心之间10-13%的认知得分差异和中心内个体之间17-36%的得分差异。结论：我们的数据表明，尽管欧洲男性认知功能的一部分差异可以用个体水平差异来解释，但很大一部分是由环境现象造成的。在分析多中心数据时需要考虑这些背景因素，在使用现有工具评估认知表现时，不应将欧洲男性视为同质性。版权所有John Wiley & Sons， Ltd. 2009
Objectives We determined levels of cognitive functioning in community dwelling men aged 40-79 (n = 3265) from eight European centres and investigated to what extent cognitive performance varied between centres, the association between different cognitive domains and age, educational level, co-morbidity and lifestyle factors and the respective contributions of centre and individual factors to cognitive performance.Methods Cognitive domains assessed were visuo-constructional ability and Visual memory (Rey-Osterrieth Complex Figure test, ROCF), topographical memory (Camden Topographical Recognition Memory test, CTRM) and processing speed (Digit-Symbol Substitution test, DSST).Results There were significant between-centre differences in all four cognitive test scores. Using multilevel linear regression analysis (MLRA), age, education, depression, physical performance and smoking were independent predictors of cognitive function and these variables explained 10-13% of the variation in cognitive scores between centres and 17-36% of the variation in scores between individuals within centres.Conclusion Our data suggest that although a proportion of the variance in cognitive function among European men is explained by individual level differences, a significant proportion is due to contextual phenomenon. Such contextual factors need to be considered when analysing multi-centre data and European men should not be treated as homogeneous when assessing cognitive performance using existing instruments. Copyright (C) 2009 John Wiley & Sons, Ltd.