The physiology and pharmacology of spinal opiates.
The physiology and pharmacology of spinal opiates.
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DOI：
10.1146/annurev.pa.25.040185.002245
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发表时间：
1985
影响因子：
12.5
通讯作者：
T. Yaksh;R. Noueihed
中科院分区：
文献类型：
--
作者：
T. Yaksh;R. Noueihed
阿片类激动剂的作用仅限于脊髓，在生物体对其他疼痛刺激的反应中产生强大的变化。我们认为，这种作用是通过对阿片受体的作用来介导的，阿片受体位于特定的脊髓元件上，介导伤害性信息的局部处理及其随后向脊髓上中心的传递。在其他地方（1-2a）综述的大量文献已经非常清楚地表明，存在几类阿片受体，包括那些具有药理学特征的受体。3、K、（J ′）和E.在下面的章节中，我们考虑目前对阿片类药物脊髓作用机制的思考，镇痛的特点，以及介导效应的受体群体的特点。最近，它已变得清晰，脊髓阿片受体也与各种系统，除了那些属于感觉调制。因此，在完整和未麻醉的麻醉动物中脊髓给予阿片类药物显示了对运动、心血管、胃肠道和膀胱功能的强大受体介导的作用。还将简要讨论这些问题。
Opioid agonists with an action limited to the spinal cord produce powerful changes in an organism's response to otherwise painful stimuli. The effect is mediated by an action on opioid receptors located, we believe, on specific spinal elements that mediate the local processing of nociceptive information and its subsequent transmission to supraspinal centers. An extensive literature, reviewed elsewhere (1-2a), has made it abundantly clear that several classes of opioid receptors exist, including those with pharmacological profiles desig nated fJ., 3, K, (J' and E. In the following section we consider current thinking on the mechanism underlying the spinal action of opioids, the characteristics of the analgesia, and the characteristics of the receptor populations that mediate effect. Recently, it has become clear that spinal opioid receptors are also associated with a variety of systems in addition to those pertaining to sensory modulation. Thus, the spinal administration of opiates in the intact and unanes thetized animal has revealed powerful receptor-mediated effects on motor, cardiovascular, gastrointestinal, and bladder function. These subjects will also be briefly addressed.