Effects of intron length on differential processing of mouse mu heavy-chain mRNA.
Effects of intron length on differential processing of mouse mu heavy-chain mRNA.
复制标题
内含子长度对小鼠 mu 重链 mRNA 差异加工的影响。
DOI：
10.1128/mcb.7.7.2602-2605.1987
复制
发表时间：
1987
影响因子：
5.3
通讯作者：
Korn,LJ
中科院分区：
文献类型：
--
作者：
Tsurushita,N;Korn,LJ
Production of membrane-bound and secreted forms of mouse μ heavy-chain mRNA is controlled by differential processing in a developmental-stage-specific manner. We have analyzed the effects of various deletions and insertions in the C4-M1 intron of the mouse μ gene on the differential processing of μ mRNA. We show that there is a correlation between the length of the C4-M1 intron and the molar ratio of membrane-bound to secreted μ mRNAs, i.e., the shorter the C4-M1 intron, the higher the ratio. Since the poly(A) addition signal in the C4-M1 intron seems to be intact in the mutant μ genes, it is likely that the efficiency of splicing of the C4-M1 intron is affected by changes in the intron length.
