Specific innervation of guinea‐pig superior cervical ganglion cells by preganglionic fibres arising from different levels of the spinal cord.
Specific innervation of guinea‐pig superior cervical ganglion cells by preganglionic fibres arising from different levels of the spinal cord.
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来自脊髓不同水平的节前纤维对豚鼠颈上神经节细胞的特异性神经支配。
DOI：
10.1113/jphysiol.1977.sp011683
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
D. Purves
中科院分区：
文献类型：
--
作者：
A. Njå;D. Purves
1.通过在体外腹根刺激期间进行细胞内记录，研究了源自最后一个颈（C8）和前七个胸脊髓节段（T1-T7）的节前神经纤维对豚鼠上级颈神经节神经元的突触贡献。2.大多数神经元接受神经支配的长度脊髓的中间段（T2和T3）的节前纤维来自;一个中间数量的神经节细胞神经支配的纤维从相邻的节段（T1，T4，和T5），和相对较少的神经元的纤维从最喙和尾段供应神经支配的神经节（C8，T6和T7）。3.每个神经元接受来自多个胸段的节前终末（范围1 - 7，平均值= 4 - 0）。估计接触每个神经元的节前纤维的最小数量平均为10根。4.一般来说，支配神经元的脊髓节段是连续的。因此，我们很少遇到的神经元位于喙部和尾部的一个段，未能提供神经支配的神经节段支配。5.神经元倾向于主要由来自单个脊髓节段的轴突支配，相邻节段的突触影响随着它们与主导节段的距离而减少。所有节段至少对某些神经元提供支配性神经支配。6.在体内刺激C8-T7的前根表明，从每个节段产生的轴突产生了外周效应的特征模式。因此，豚鼠上级颈神经节中的不同神经元群受到来自脊髓不同水平的节前轴突的神经支配，正如兰利（1892）最初对猫、狗和兔提出的那样。7.在我们的体外研究的基础上，我们得出结论，潜在的特异性神经支配的上级颈神经节，可以推断从体内实验是一种趋势，个别神经元的神经支配在一个系统分级的方式由一个连续的子集的8个脊髓节段提供神经支配的神经节。
1. The synaptic contribution of preganglionic nerve fibres arising from the last cervical (C8) and the first seven thoracic spinal cord segments (T1‐T7) to neurones of the guinea‐pig superior cervical ganglion has been studied by means of intracellular recording during ventral root stimulation in vitro. 2. The majority of neurones received innervation from the middle segments (T2 and T3) of the length of spinal cord from which preganglionic fibres derive; an intermediate number of ganglion cells were innervated by fibres from the segments adjacent to these (T1, T4, and T5), and relatively few neurones by fibres from the most rostral and caudal segments supplying innervation to the ganglion (C8, T6 and T7). 3. Each neurone received preganglionic terminals from multiple thoracic segments (range 1‐7, mean = 4‐0). The estimated minimum number of preganglionic fibres contacting each neurone was 10, on average. 4. As a rule, the spinal segments innervating a neurone were contiguous. Thus we rarely encountered neurones innervated by segments located both rostrally and caudally to a segment which failed to provide innervation. 5. Neurones tended to be innervated predominantly by axons arising from a single spinal segment, with adjacent segments contributing a synaptic influence that diminished as a function of their distance from the dominant segment. All segments provided dominant innervation to at least some neurones. 6. Stimulating the ventral roots of C8‐T7 in vivo showed that the axons arising from each segment produced a characteristic pattern of peripheral effects. Thus different populations of neurones in the superior cervical ganglion of the guinea‐pig are innervated by preganglionic axons from different levels of the spinal cord, as originally suggested by Langley (1892) for the cat, dog, and rabbit. 7. On the basis of our in vitro studies we conclude that underlying the specificity of innervation of neurones of the superior cervical ganglion that can be inferred from in vivo experiments is a tendency for individual neurones to be innervated in a systematically graded fashion by a contiguous subset of the eight spinal segments which provide innervation to the ganglion.