Molecular structure of frizzled, a Drosophila tissue polarity gene.
Molecular structure of frizzled, a Drosophila tissue polarity gene.
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发表时间：
1990-10
期刊：
影响因子：
3.3
通讯作者：
Paul N. Adler;Charles Vinson, 'woo;Jin Park;S. Conover;Lisa Klein
中科院分区：
文献类型：
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作者：
Paul N. Adler;Charles Vinson, 'woo;Jin Park;S. Conover;Lisa Klein
卷曲（fz）位点的功能是协调蛹表皮细胞的细胞骨架，从而产生平行的角质层毛和刚毛。本文报道了fz基因座的分子克隆和特征。轨迹非常大。使基因失活的突变分布在100 kb的基因组DNA中。该基因的主要mRNA产物是一个4kb的RNA，由分布在超过90kb的基因组DNA上的5个外显子编码。这种mRNA的概念翻译表明，它编码一个完整的膜蛋白，可能包含细胞外和细胞质结构域。
The function of the frizzled (fz) locus is required to coordinate the cytoskeletons of pupal epidermal cells so that a parallel array of cuticular hairs and bristles is produced. We report here the molecular cloning and characterization of the fz locus. The locus is very large. Mutations that inactivate the gene are spread over 100 kb of genomic DNA. The major mRNA product of the gene is a 4-kb RNA that is encoded by 5 exons spread over more than 90 kb of genomic DNA. Conceptual translation of this mRNA indicates that it encodes an integral membrane protein that is likely to contain both extracellular and cytoplasmic domains.