Recent advances in the application of metabolomics to Alzheimer's Disease.
Recent advances in the application of metabolomics to Alzheimer's Disease.
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DOI：
10.1016/j.bbadis.2013.06.014
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发表时间：
2014-08
影响因子：
6.2
通讯作者：
Mielke, Michelle M.
中科院分区：
文献类型：
--
作者：
Trushina, Eugenia;Mielke, Michelle M.
The pathophysiological changes associated with Alzheimer’s Disease (AD) begin decades before the emergence of clinical symptoms. Understanding the early mechanisms associated with AD pathology is, therefore, especially important for identifying disease-modifying therapeutic targets. While the majority of AD clinical trials to date have focused on anti-amyloid-beta (Aβ) treatments, other therapeutic approaches may be necessary. The ability to monitor changes in cellular networks that include both Aβ and non-Aβ pathways is essential to advance our understanding of the etiopathogenesis of AD and subsequent development of cognitive symptoms and dementia. Metabolomics is a powerful tool that detects perturbations in the metabolome, a pool of metabolites that reflects changes downstream of genomic, transcriptomic and proteomic fluctuations, and represents an accurate biochemical profile of the organism in health and disease. The application of metabolomics could help to identify biomarkers for early AD diagnosis, to discover novel therapeutic targets, and to monitor therapeutic response and disease progression. Moreover, given the considerable parallel between mouse and human metabolism, the use of metabolomics provides ready translation of animal research into human studies for accelerated drug design. In this review, we will summarize current progress in the application of metabolomics in both animal models and in humans to further understanding of the mechanisms involved in AD pathogenesis.
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DOI：
10.1016/j.jalz.2010.06.001
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
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通讯作者：
Welsh-Bohmer KA
DOI：
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发表时间：
2012-12
期刊：
The Lancet. Neurology
影响因子：
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通讯作者：
Reiman EM
影响因子：
158.5
作者：
Howard, Robert;McShane, Rupert;Phillips, Patrick
通讯作者：
Phillips, Patrick
早期阿尔茨海默病的代谢组学：使用鸟枪脂质组学鉴定改变的血浆鞘脂组。
影响因子：
3.7
作者：
Han X;Rozen S;Boyle SH;Hellegers C;Cheng H;Burke JR;Welsh-Bohmer KA;Doraiswamy PM;Kaddurah-Daouk R
通讯作者：
Kaddurah-Daouk R
DOI：
10.1073/pnas.0305799101
发表时间：
2004-02-17
影响因子：
11.1
作者：
Cutler, RG;Kelly, J;Mattson, MP
通讯作者：
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