The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.
The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.
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DOI：
10.1111/j.1755-148x.2009.00585.x
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发表时间：
2009-08
影响因子：
4.3
通讯作者：
Robertson GP
中科院分区：
文献类型：
--
作者：
Madhunapantula SV;Robertson GP
Melanocytes undergo extensive genetic changes during transformation into aggressive melanomas. These changes deregulate genes whose aberrant activity promotes the development of this disease. The PI3K (phosphoinositide 3-kinase) and MAP (mitogen-activated protein) kinase pathways are two key signaling cascades that have been found to play prominent roles in melanoma development. These pathways relay extra-cellular signals via an ordered series of consecutive phosphorylation events from cell surface throughout the cytoplasm and nucleus regulating diverse cellular processes including proliferation, survival, invasion and angiogenesis. It is generally accepted that therapeutic agents would need to target these two pathways to be an effective therapy for the long-term treatment of advanced-stage melanoma patients. This review provides an overview of the PI3 kinase pathway focusing specifically on two members of the pathway, called PTEN and Akt3, which play important roles in melanoma development. Mechanisms leading to deregulation of these two proteins and therapeutic implications of targeting this signaling cascade to treat melanoma are detailed in this review.
