Brain repair and neuroprotection by serum insulin-like growth factor I
Brain repair and neuroprotection by serum insulin-like growth factor I
复制标题
血清胰岛素样生长因子I对脑损伤的修复和神经保护作用
DOI：
10.1385/mn:27:2:153
复制
发表时间：
2003-04-01
影响因子：
5.1
通讯作者：
Torres-Aleman, I
中科院分区：
文献类型：
--
作者：
Carro, E;Trejo, JL;Torres-Aleman, I
成人大脑中保护机制的存在正逐渐被认为是大脑功能的一个重要方面。多年来，胚胎后大脑的自我修复过程被认为是次要的或不存在的。这一概念主导了神经营养作用的研究。因此，尽管神经营养因子参与成年脑功能的可能性得到了谨慎的维护，但大多数关于营养因子在脑中作用的研究都集中在发育方面。随着最近认识到成人大脑保持细胞更新的能力，尽管有限，但对脑组织再生特性的新兴趣已经出现。胰岛素样生长因子I（IGF-I）是一种血清中高水平存在的有效神经营养肽，其作用的新发现可能说明了这一趋势。循环中的IGF-I是成人正常脑功能的重要决定因素。它的多效性作用范围从对神经元的经典营养作用，如管家或抗凋亡/促存活作用，到调节脑屏障通透性、神经元兴奋性或新神经元形成。最近的研究结果表明，IGF-I参与生理相关的神经保护机制，如体育锻炼引发的机制。越来越多的神经营养功能显示血清IGF-I强化了IGF-I形成的生理神经保护网络的观点，可能还有其他尚未表征的信号。未来对IGF-I的研究，以及其他神经营养因子的研究，必将揭示并教会我们如何增强成人大脑的自我修复能力。
The existence of protective mechanisms in the adult brain is gradually being recognized as an important aspect of brain function. For many years, self-repair processes in the post-embryonic brain were considered of minor consequence or nonexistent. This notion dominated the study of neurotrophism. Thus, although the possibility that neurotrophic factors participate in brain function in adult life was prudently maintained, the majority of the studies on the role of trophic factors in the brain were focused on developmental aspects. With the recent recognition that the adult brain keeps a capacity for cell renewal, although limited, a new interest in the regenerative properties of brain tissue has emerged. New findings on the role of insulin-like growth factor I (IGF-I), a potent neurotrophic peptide present at high levels in serum, may illustrate this current trend. Circulating IGF-I is an important determinant of proper brain function in the adult. Its pleiotropic effects range from classical trophic actions on neurons such as housekeeping or anti-apoptotic/pro-survival effects to modulation of brain-barrier permeability, neuronal excitability, or new neuron formation. More recent findings indicate that IGF-I participates in physiologically relevant neuroprotective mechanisms such as those triggered by physical exercise. The increasing number of neurotrophic features displayed by serum IGF-I reinforces the view of a physiological neuroprotective network formed by IGF-I, and possibly other still uncharacterized signals. Future studies with IGF-I, and hopefully other neurotrophic factors, will surely reveal and teach us how to potentiate the self-reparative properties of the adult brain.