Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice
Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice
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DOI：
10.1016/j.tcb.2008.06.001
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发表时间：
2008-08-01
影响因子：
19
通讯作者：
Vincent, Jean-Paul
中科院分区：
文献类型：
--
作者：
Beckett, Karen;Franch-Marro, Xavier;Vincent, Jean-Paul
Glypicans是糖基化磷脂酰肌醇连接的硫酸乙酰肝素蛋白多糖，在形态信号的调节中发挥重要作用。使用果蝇和小鼠的两个新报告强调了字形内吞作用在调节Hedgehog(HH)信号和在无翼梯度形成中的重要性。一只果蝇Glypica，Daily-like，在HH信号中起积极作用，而小鼠Glypcan-3是负调节因子。这种差异似乎依赖于Glypicans是单独促进HH的内化，还是作为其受体Patted的复合体促进HH内化。
Glypicans are glycosylphosphatidylinositol-linked heparan sulfate proteoglycans that play an essential part in the regulation of morphogen signalling. Two new reports using Drosophila and mice have highlighted the importance of glypican endocytosis in the regulation of Hedgehog (Hh) signalling and in Wingless gradient formation. One Drosophila glypican, Daily-like, acts positively in Hh signalling, whereas mouse Glypican-3 is a negative regulator. This difference seems to be dependent on whether glypicans promote the internalization of Hh alone or as a complex with its receptor, Patched.