Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease
Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease
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DOI：
10.1016/j.jns.2006.05.062
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发表时间：
2006-11-01
影响因子：
4.4
通讯作者：
Fregni, Felipe
中科院分区：
文献类型：
--
作者：
Boggio, Paulo S.;Ferrucci, Roberta;Fregni, Felipe
目的：认知功能障碍是帕金森病（PD）的常见特征，是生活质量的重要预测因子。过去的研究表明，多巴胺能治疗和经颅磁刺激可以增强认知的某些方面，如工作记忆。我们的研究的目的是调查是否另一种形式的非侵入性脑刺激，阳极经颅直流电刺激（tDCS），增加皮层兴奋性，与PD patients.Methods的工作记忆任务性能的变化：我们研究了18例（12名男性和6名女性）与特发性PD。患者在左背外侧前额叶皮层（LDLPFC）的活动性阳极tDCS、初级运动皮层（M1）的阳极tDCS或假tDCS期间执行三背工作记忆任务。此外，患者进行了两种不同类型的刺激，具有不同的强度：1和2 mA.Results：本研究的结果表明，在工作记忆的任务准确性指数显着改善后，积极的阳极tDCS的LDLPFC与2 mA。其他条件的刺激：假tDCS，阳极tDCS的LDLPFC与I mA或阳极tDCS的M I并没有导致一个显着的任务performance.Conclusion：tDCS可能会产生有益的影响PD患者的工作记忆，这取决于刺激的强度和部位。这种效应可能是由背外侧前额叶皮层的兴奋性局部增加来解释的。(c)2006 Elsevier B.V.保留所有权利。
Objectives: Cognitive impairment is a common feature in Parkinson's disease (PD) and is an important predictor of quality of life. Past studies showed that some aspects of cognition, such as working memory, can be enhanced following dopaminergic therapy and transcranial magnetic stimulation. The aim of our study was to investigate whether another form of noninvasive brain stimulation, anodal transcranial direct current stimulation (tDCS), which increases cortical excitability, is associated with a change in a working memory task performance in PD patients.Methods: We studied 18 patients (12 men and 6 women) with idiopathic PD. The patients performed a three-back working memory task during active anodal tDCS of the left dorsolateral prefrontal cortex (LDLPFC), anodal tDCS of the primary motor cortex (M1) or sham tDCS. In addition, patients underwent two different types of stimulation with different intensities: 1 and 2 mA.Results: The results of this study show a significant improvement in working memory as indexed by task accuracy, after active anodal tDCS of the LDLPFC with 2 mA. The other conditions of stimulation: sham tDCS, anodal tDCS of LDLPFC with I mA or anodal tDCS of M I did not result in a significant task performance change.Conclusion: tDCS may exert a beneficial effect on working memory in PD patients that depends on the intensity and site of stimulation. This effect might be explained by the local increase in the excitability of the dorsolateral prefrontal cortex. (c) 2006 Elsevier B.V. All rights reserved.