Potential application of mesenchymal stem cells in acute lung injury.
Potential application of mesenchymal stem cells in acute lung injury.
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DOI：
10.1517/14712590903213651
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发表时间：
2009-10
影响因子：
4.6
通讯作者：
Matthay MA
中科院分区：
文献类型：
--
作者：
Lee JW;Gupta N;Serikov V;Matthay MA
尽管对急性肺损伤和急性呼吸窘迫综合征（ALI/ARDS）的发病机制进行了广泛的研究，但死亡率仍然高达约40%。目前的治疗主要是支持，肺保护通气和液体保守策略。在实验研究中减少肺损伤严重程度的药物治疗尚未转化为有效的临床治疗方案。因此，需要创新的治疗方法。最近的研究表明，骨髓来源的多能间充质干细胞（MSC）可能在多种临床疾病，包括心肌梗死，糖尿病，败血症，肝脏和急性肾功能衰竭的治疗应用。最近，MSC在几种肺疾病的体内模型中进行了研究。本文首先介绍了在ALI/ARDS模型中使用MSC的现有实验文献，然后重点介绍了其治疗作用的潜在机制，并强调了分泌的旁分泌可溶性因子。综述最后讨论了潜在临床试验所需的未来研究方向。
Despite extensive research into the pathogenesis of acute lung injury and the acute respiratory distress syndrome (ALI/ARDS), mortality remains high at approximately 40%. Current treatment is primarily supportive, with lung-protective ventilation and a fluid conservative strategy. Pharmacologic therapies that reduce the severity of lung injury in experimental studies have not yet been translated into effective clinical treatment options. Therefore, innovative therapies are needed. Recent studies have suggested that bone-marrow-derived multipotent mesenchymal stem cells (MSC) may have therapeutic applications in multiple clinical disorders including myocardial infarction, diabetes, sepsis, hepatic and acute renal failure. Recently, MSC have been studied in several in vivo models of lung disease. This review focuses on first describing the existing experimental literature that has tested the use of MSC in models of ALI/ARDS, and then the potential mechanisms underlying their therapeutic use with an emphasis on secreted paracrine soluble factors. The review concludes with a discussion of future research directions required for potential clinical trials.
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影响因子：
4.4
作者：
Gupta, Naveen;Su, Xiao;Matthay, Michael A.
通讯作者：
Matthay, Michael A.
影响因子：
8.8
作者：
Dada, LA;Sznajder, JI
通讯作者：
Sznajder, JI
DOI：
10.1016/j.bbrc.2007.01.045
发表时间：
2007-03-16
影响因子：
3.1
作者：
Iso, Yoshitaka;Spees, Jeffrey L.;Prockop, Darwin J.
通讯作者：
Prockop, Darwin J.
影响因子：
3.7
作者：
Hung SC;Pochampally RR;Hsu SC;Sanchez C;Chen SC;Spees J;Prockop DJ
通讯作者：
Prockop DJ
影响因子：
20.3
作者：
Aggarwal, S;Pittenger, MF
通讯作者：
Pittenger, MF