The Potential Clinical Utility of Transdermal Alcohol Monitoring Data to Estimate the Number of Alcoholic Drinks Consumed.
The Potential Clinical Utility of Transdermal Alcohol Monitoring Data to Estimate the Number of Alcoholic Drinks Consumed.
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DOI：
10.1097/adt.0000000000000060
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发表时间：
2015-09
影响因子：
1.1
通讯作者：
Roache JD
中科院分区：
文献类型：
--
作者：
Dougherty DM;Hill-Kapturczak N;Liang Y;Karns TE;Lake SL;Cates SE;Roache JD
经皮酒精监测在法医环境中被广泛使用，以确定个人是否违反了法院命令的戒酒命令。尽管在这种情况下被广泛使用，但相对较少的研究探索了经皮酒精监测的临床实用价值。此外，在进行的为数不多的研究中，大多数都依赖于法医确立的保守标准来确定是否发生了饮酒事件。在这里，我们探索如何使用经皮酒精监测数据来估计与临床治疗计划相关的更有临床意义的参数。我们开发了一种程序，使用经皮数据客观地估计个人消费的标准化饮料的数量。参与者包括46名男性和女性，他们在不同的日子里在实验室的2小时内喝下1到5瓶啤酒，同时佩戴监测经皮酒精浓度(TAC)的设备。建立了一个数学模型来估计标准化酒精饮料的消耗量，其中包括一些变量(到达峰值的时间、TAC曲线下的面积和性别)。然后，将该模型应用于另一项研究的数据，对其进行了验证。我们的结果表明，透皮酒精装置可以用来估计标准饮料的消耗量。目的确定中毒程度和饮酒量的方法，如经皮酒精监测，在研究和治疗环境中都是有用的。
Transdermal alcohol monitoring is used extensively in forensic settings to identify whether individuals have violated court-ordered mandates to abstain from drinking. Despite widespread use in that setting, comparatively few studies have explored the clinical utility of transdermal alcohol monitoring. Furthermore, of the few studies conducted, most have relied on the forensically established conservative criteria to identify whether or not a drinking episode has occurred. Here, we explore how transdermal alcohol monitoring data can be used to estimate more clinically meaningful parameters relevant to clinical treatment programs. We developed a procedure to use transdermal data to objectively estimate the number of standardized drinks an individual has consumed. Participants included 46 men and women who consumed 1 to 5 beers within 2 hours in the laboratory on separate days while wearing devices to monitor transdermal alcohol concentrations (TAC). A mathematical model was derived to estimate the number of standardized alcohol drinks consumed, which included a number of variables (time-to-peak TAC, area under the TAC curve, and sex). The model was then validated by applying it to data from a separate study. Our results indicate that transdermal alcohol devices can be used to estimate the number of standard drinks consumed. Objective methods characterizing both the level of intoxication achieved and the number of drinks consumed, such as transdermal alcohol monitoring, could be useful in both research and treatment settings.