Parametric Imaging and Test-Retest Variability of 11C-(+)-PHNO Binding to D2/D3 Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner
Parametric Imaging and Test-Retest Variability of 11C-(+)-PHNO Binding to D2/D3 Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner
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DOI：
10.2967/jnumed.113.132928
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发表时间：
2014-06-01
影响因子：
9.3
通讯作者：
Malison, Robert T.
中科院分区：
文献类型：
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作者：
Gallezot, Jean-Dominique;Zheng, Ming-Qiang;Malison, Robert T.
C-11-(+)-4-丙基-9-羟基萘恶嗪（C-11-(+)- phno）是一种激动剂放射配体，用于PET成像人脑多巴胺D-2和D-3受体。在这项研究中，我们使用日内设计评估了C-11-(+)- phno结合参数的可重复性，并评估了参数成像方法。方法：对8例受试者进行重复研究，同时测定动脉输入功能和血浆游离分数。同一受试者的两次C-11-(+)- phno扫描间隔5.4 +/- 0.7 h。在评估室模型后，使用多元线性分析MA1方法定量C-11-(+)- phno分布体积（V-T）和结合电位相对于血浆中示踪剂（BPP）、组织中不可置换示踪剂（BPND）和组织中游离示踪剂（BPF）的浓度，以小脑为参考区。采用简化参考组织模型（SRTM）和SRTM2计算BPND的参数图像。结果：C-11-(+)- phno BPND在富含d -2的区域（尾状核和壳核）的重测变异性为9%。在富含d -3的区域中，苍白质的可变性较低（6%），但黑质（19%）、丘脑（14%）和下丘脑（21%）的可变性较高。在富含d -3的区域没有观察到明显的质量携带效应，尽管黑质中存在BPND的趋势（-14% +/- 15%）。由于相对较快的动力学特性，采用SRTM和SRTM2均可获得低噪声的BPND参数图像，且无需空间平滑。结论：C-11-(+)- phno可用于计算人体富含D-2和d -3区域的低噪声参数图像。
C-11-(+)-4-propyl-9-hydroxynaphthoxazine (C-11-(+)-PHNO) is an agonist radioligand for imaging dopamine D-2 and D-3 receptors in the human brain with PET. In this study we evaluated the reproducibility of C-11-(+)-PHNO binding parameters using a within-day design and assessed parametric imaging methods. Methods: Repeated studies were performed in 8 subjects, with simultaneous measurement of the arterial input function and plasma free fraction. Two C-11-(+)-PHNO scans for the same subject were separated by 5.4 +/- 0.7 h. After compartment models were evaluated, C-11-(+)-PHNO volumes of distribution (V-T) and binding potentials relative to the concentration of tracer in plasma (BPP), nondisplaceable tracer in tissue (BPND), and free tracer in tissue (BPF) were quantified using the multilinear analysis MA1 method, with the cerebellum as the reference region. Parametric images of BPND were also computed using the simplified reference tissue model (SRTM) and SRTM2. Results: The test-retest variability of C-11-(+)-PHNO BPND was 9% in D-2-rich regions (caudate and putamen). Among D-3-rich regions, variability was low in the pallidum (6%) but higher in substantia nigra (19%), thalamus (14%), and hypothalamus (21%). No significant mass carry-over effect was observed in D-3-rich regions, although a trend in BPND was present in the substantia nigra (-14% +/- 15%). Because of the relatively fast kinetics, low-noise BPND parametric images were obtained with both SRTM and SRTM2 without spatial smoothing. Conclusion: C-11-(+)-PHNO can be used to compute low-noise parametric images in both D-2- and D-3-rich regions in humans.