A Critical Balance: dNTPs and the Maintenance of Genome Stability.
A Critical Balance: dNTPs and the Maintenance of Genome Stability.
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DOI：
10.3390/genes8020057
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发表时间：
2017-01-31
期刊：
影响因子：
3.5
通讯作者：
Kearsey SE
中科院分区：
文献类型：
--
作者：
Pai CC;Kearsey SE
维持基因组稳定性的一个关键因素是将脱氧核苷三磷酸 (dNTP) 水平确定在最适合染色体复制的范围内。由于 DNA 复制与多种其他染色体活动相关，因此当 dNTP 浓度偏离生理正常范围时，这些活动都可能受到直接或间接影响。了解这些后果的重要性与扰乱 dNTP 水平的遗传性疾病以及在癌症化疗和其他疾病治疗中抑制 dNTP 合成的策略相关。我们在此回顾异常 dNTP 水平如何影响 DNA 复制，并讨论其对基因组稳定性的影响。
A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a physiologically normal range. The importance of understanding these consequences is relevant to genetic disorders that disturb dNTP levels, and strategies that inhibit dNTP synthesis in cancer chemotherapy and for treatment of other disorders. We review here how abnormal dNTP levels affect DNA replication and discuss the consequences for genome stability.